{"id":"cetirizine-dry-syrup","safety":{"commonSideEffects":[{"rate":"2-3","effect":"Headache"},{"rate":"1-2","effect":"Somnolence"},{"rate":"1-2","effect":"Pharyngitis"},{"rate":"1-2","effect":"Dry mouth"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cetirizine competitively binds to peripheral H1-receptors on mast cells and basophils, preventing histamine from triggering allergic cascade reactions. This reduces symptoms of allergies including itching, urticaria, and rhinitis. As a second-generation antihistamine, it has minimal central nervous system penetration due to its hydrophilic nature and low blood-brain barrier crossing.","oneSentence":"Cetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:05:23.089Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Chronic urticaria"},{"name":"Allergic conjunctivitis"}]},"trialDetails":[{"nctId":"NCT00490204","phase":"PHASE3","title":"Cetirizine Placebo Controlled Study For Perennial Allergic Rhinitis","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-07-27","conditions":"Rhinitis, Allergic, Perennial","enrollment":239},{"nctId":"NCT01622283","phase":"PHASE1","title":"Pharmacokinetic Study of Levocetirizine Oral Solution","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2012-05-02","conditions":"Rhinitis, Allergic, Perennial and Seasonal","enrollment":20},{"nctId":"NCT00257595","phase":"PHASE3","title":"Perennial Allergic Rhinitis In Pediatric Subjects","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-08","conditions":"Rhinitis, Allergic, Perennial","enrollment":30},{"nctId":"NCT00257582","phase":"PHASE3","title":"Study Of Cutaneous Disease Accompanied With Pruritus In Pediatrics","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-08","conditions":"Pruritus","enrollment":60},{"nctId":"NCT00257569","phase":"PHASE3","title":"Study Of Atopic Dermatitis In Pediatrics","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-08","conditions":"Dermatitis, Atopic","enrollment":278},{"nctId":"NCT00253058","phase":"PHASE3","title":"Study Of Perennial Allergic Rhinitis In Pediatrics","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-07","conditions":"Rhinitis, Allergic, Perennial","enrollment":286},{"nctId":"NCT00639587","phase":"PHASE3","title":"Efficacy and Safety of Cetirizine Tablets Versus Ketotifen Dry Syrup in Children With Perennial Allergic Rhinitis","status":"COMPLETED","sponsor":"UCB Pharma","startDate":"2002-08","conditions":"Rhinitis, Allergic, Perennial","enrollment":149}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Cetirizine Dry Syrup","genericName":"Cetirizine Dry Syrup","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses. Used for Allergic rhinitis, Chronic urticaria, Allergic conjunctivitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}