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levocetirizine (Xyzal)
levocetirizine (Xyzal) is a H1-receptor antagonist (second-generation antihistamine) Small molecule drug developed by AAADRS Clinical Research Center. It is currently FDA-approved for Allergic rhinitis (seasonal and perennial), Chronic urticaria, Allergic conjunctivitis. Also known as: Xyzal.
Levocetirizine is a selective H1-receptor antagonist that blocks histamine signaling to reduce allergic symptoms.
Levocetirizine is a selective H1-receptor antagonist that blocks histamine signaling to reduce allergic symptoms. Used for Allergic rhinitis (seasonal and perennial), Chronic urticaria, Allergic conjunctivitis.
At a glance
| Generic name | levocetirizine (Xyzal) |
|---|---|
| Also known as | Xyzal |
| Sponsor | AAADRS Clinical Research Center |
| Drug class | H1-receptor antagonist (second-generation antihistamine) |
| Target | H1 receptor |
| Modality | Small molecule |
| Therapeutic area | Allergy/Immunology |
| Phase | FDA-approved |
Mechanism of action
Levocetirizine is the active R-enantiomer of cetirizine, a second-generation antihistamine that selectively antagonizes peripheral H1 receptors. By blocking histamine binding to these receptors, it prevents the cascade of allergic responses including itching, urticaria, and rhinitis without significant central nervous system penetration due to its hydrophilic nature and poor blood-brain barrier crossing.
Approved indications
- Allergic rhinitis (seasonal and perennial)
- Chronic urticaria
- Allergic conjunctivitis
Common side effects
- Somnolence
- Headache
- Fatigue
- Dry mouth
- Pharyngitis
Key clinical trials
- Intravenous Immunoglobulin for the Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis (PHASE3)
- Steroid Use in Treatment of Allergic Reactions to Food (PHASE4)
- Efficacy of Bilastine Up-dosing (40 mg ) Versus Combination of Bilastine (20 mg )With Levocitirizine (5 mg) in the Treatment of Chronic Spontaneous Urticaria (NA)
- Traditional vs. Posterior Nasal Radiofrequency Ablation for Chronic Rhinitis (NA)
- Parallel, Double-dummy, Superiority Study Levocetirizine/Pseudoephedrine x Zina for Allergic Rhinitis in Brazil (PHASE3)
- COrticosteroids in acUte uRticAria in emerGency dEpartment (PHASE3)
- A Histamine Pharmacodynamic Biomarker to Guide Treatment in Pediatric Asthma (HAS3) (PHASE3)
- A Trial of Camrelizumab Plus Nab-paclitaxel and Levocetirizine in Metastatic or Recurrent TNBC (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- levocetirizine (Xyzal) CI brief — competitive landscape report
- levocetirizine (Xyzal) updates RSS · CI watch RSS
- AAADRS Clinical Research Center portfolio CI
Frequently asked questions about levocetirizine (Xyzal)
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Is levocetirizine (Xyzal) also known as anything else?
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Related
- Drug class: All H1-receptor antagonist (second-generation antihistamine) drugs
- Target: All drugs targeting H1 receptor
- Manufacturer: AAADRS Clinical Research Center — full pipeline
- Therapeutic area: All drugs in Allergy/Immunology
- Indication: Drugs for Allergic rhinitis (seasonal and perennial)
- Indication: Drugs for Chronic urticaria
- Indication: Drugs for Allergic conjunctivitis
- Also known as: Xyzal
- Compare: levocetirizine (Xyzal) vs similar drugs
- Pricing: levocetirizine (Xyzal) cost, discount & access