Factor Xa — Drug Target
All drugs that target Factor Xa — marketed and clinical-stage. Includes 6 drug classes acting on this target.
Drug classes
Factor Xa inhibitor · Direct Factor Xa inhibitor · Direct Oral Anticoagulant · Monoclonal Antibody · Low-molecular-weight heparin (LMWH); Factor Xa inhibitor · Anticoagulant
Marketed (16)
- low-dose rivaroxaban · China National Center for Cardiovascular Diseases · Factor Xa inhibitor · Cardiovascular
Low-dose rivaroxaban selectively inhibits Factor Xa in the coagulation cascade, reducing thrombin generation and blood clot formation at a lower dose than standard anticoagulation. - Rivaroxaban (Xarelto) · University of Michigan · Direct Factor Xa inhibitor · Cardiovascular
Rivaroxaban is a direct Factor Xa inhibitor that blocks a key enzyme in the blood coagulation cascade, preventing thrombin generation and clot formation. - No OAC · Pfizer · Direct Oral Anticoagulant · Cardiovascular
- Hympavzi · Pfizer Inc · Monoclonal Antibody · Rare Disease
Hympavzi works by binding to Factor Xa, a protein involved in blood clotting. - Fondaparinux Sodium (Arixtra) · Paul Di Cesare,MD · Factor Xa inhibitor · Cardiovascular
Fondaparinux selectively inhibits Factor Xa, a key enzyme in the coagulation cascade, preventing thrombin generation and blood clot formation. - Oroxid® · Charles University, Czech Republic · Direct Factor Xa inhibitor · Cardiovascular
Oroxid is an oral anticoagulant that inhibits Factor Xa in the coagulation cascade to prevent thrombus formation. - Uninterrupted apixaban · Baim Institute for Clinical Research · Factor Xa inhibitor · Cardiovascular
Apixaban is a Factor Xa inhibitor that prevents blood clot formation by blocking a key enzyme in the coagulation cascade. - rivaroxaban (10mg) · Chang Gung Memorial Hospital · Direct Factor Xa inhibitor · Cardiovascular
Rivaroxaban is a direct Factor Xa inhibitor that blocks a key enzyme in the blood coagulation cascade, preventing thrombin generation and clot formation. - Open label fondaparinux · GlaxoSmithKline · Factor Xa inhibitor · Cardiovascular
Fondaparinux selectively inhibits Factor Xa, a key enzyme in the coagulation cascade, thereby preventing thrombin generation and blood clot formation. - Apixaban single dose · Universitaire Ziekenhuizen KU Leuven · Direct Factor Xa inhibitor · Cardiovascular
Apixaban is a direct Factor Xa inhibitor that blocks the coagulation cascade to prevent blood clot formation. - Rivaroxaban 10 milligram Oral Tablet · Florida Orthopaedic Institute · Direct Factor Xa inhibitor · Cardiovascular
Rivaroxaban is a direct Factor Xa inhibitor that blocks a key enzyme in the blood coagulation cascade, preventing thrombin generation and clot formation. - ACB · NYU Langone Health · Factor Xa inhibitor · Cardiovascular
ACB is an anticoagulant that works by inhibiting Factor Xa. - Rivaroxaban Oral Tablet · Swiss Paraplegic Research, Nottwil · Direct Factor Xa inhibitor · Cardiovascular
Rivaroxaban is a direct Factor Xa inhibitor that blocks the coagulation cascade to prevent blood clot formation. - Apixaban 2.5 milligram · McMaster University · Direct Factor Xa inhibitor · Cardiovascular
Apixaban is a direct Factor Xa inhibitor that blocks the coagulation cascade to prevent blood clot formation. - RB · Kim, Seok Jin · Factor Xa inhibitor · Cardiovascular
Rivaroxaban is an anticoagulant that works by inhibiting Factor Xa. - ACL/FOR · Queen's University · Factor Xa inhibitor · Cardiovascular
ACL/FOR is a medication that helps to prevent blood clots from forming in the heart.
Phase 3 pipeline (13)
- BAY 59-7939 · Bayer · Direct Factor Xa inhibitor · Cardiovascular
BAY 59-7939 is a direct Factor Xa inhibitor that blocks the coagulation cascade to prevent thrombus formation. - Therapeutic dose anticoagulation · UMC Utrecht · Factor Xa inhibitor · Cardiovascular
Direct Factor Xa inhibition prevents the coagulation cascade. - Fondaparinux Injectable Product · Queen Mary University of London · Factor Xa inhibitor · Cardiovascular
Fondaparinux is a synthetic anticoagulant that selectively inhibits Factor Xa, preventing thrombin generation and blood clot formation. - Orafang Tab · Taejoon Pharmaceutical Co., Ltd. · Direct Factor Xa inhibitor · Cardiovascular
Orafang is an oral anticoagulant that inhibits Factor Xa in the coagulation cascade to prevent thrombus formation. - Rivaroxaban 10 Milligrams · Ahmed AbdelMoneim Hassan Ali · Direct Factor Xa inhibitor · Cardiovascular
Rivaroxaban is a direct Factor Xa inhibitor that blocks the coagulation cascade to prevent blood clot formation. - Rivaroxaban (BAY59-7939) · Bayer · Factor Xa inhibitor · Cardiovascular
Rivaroxaban is a direct Factor Xa inhibitor that prevents the coagulation cascade. - Anticoagulant treatment Rivaroxaban · Rennes University Hospital · Direct Factor Xa inhibitor · Cardiovascular
Rivaroxaban is a direct Factor Xa inhibitor that blocks the coagulation cascade to prevent blood clot formation. - Open-label Semuloparin sodium · Sanofi · Low-molecular-weight heparin (LMWH); Factor Xa inhibitor · Cardiovascular
Semuloparin sodium is a selective inhibitor of Factor Xa that prevents thrombin generation and blood clot formation. - Prevention of Venous Thromboembolism · Prof. Stavros Konstantinides, MD · Anticoagulant · Cardiovascular
This drug prevents the formation of blood clots in the veins by inhibiting the coagulation cascade. - fondaparinux - UFH not indicated · GlaxoSmithKline · Factor Xa inhibitor · Cardiovascular
Fondaparinux is a synthetic anticoagulant that selectively inhibits factor Xa. - Placebo: tablet of Rivaroxaban · Bayer · Factor Xa inhibitor · Cardiovascular
Rivaroxaban is a direct Factor Xa inhibitor that prevents the coagulation cascade. - Sefaxersen (RO7434656) · Hoffmann-La Roche · Factor Xa inhibitor · Cardiovascular
Sefaxersen is a direct Factor Xa inhibitor. - DU-176b (edoxaban) · Daiichi Sankyo Co., Ltd. · Direct Factor Xa inhibitor · Cardiovascular
Edoxaban is a direct Factor Xa inhibitor that blocks the coagulation cascade to prevent blood clot formation.
Phase 1 pipeline (1)
- Apixaban MR2 · Pfizer · Factor Xa inhibitor · Cardiovascular
Factor Xa inhibitor