Factor Xa inhibitor

This page covers all Factor Xa inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Factor Xa (FXa), Coagulation factor X, Factor Xa.

Targets

Factor Xa (FXa) · Coagulation factor X · Factor Xa · Factor Xa (Coagulation Factor X, activated form) · Factor Xa (Coagulation Factor X, activated)

Marketed (11)

• Eliquis · Bristol-Myers Squibb · Cardiovascular · 14443
  Apixaban selectively inhibits Factor Xa, decreasing thrombin generation and thrombus development.
• Savaysa · Daiichi Sankyo Inc · Cardiovascular · 1800
  Savaysa works by blocking the action of coagulation factor X, a key protein involved in blood clotting.
• ACL/FOR · Queen's University · Cardiovascular
  ACL/FOR is a medication that helps to prevent blood clots from forming in the heart.
• Bevyxxa · Portola Pharms Inc · Cardiovascular
• ACB · NYU Langone Health · Cardiovascular
  ACB is an anticoagulant that works by inhibiting Factor Xa.
• Open label fondaparinux · GlaxoSmithKline · Cardiovascular
  Fondaparinux selectively inhibits Factor Xa, a key enzyme in the coagulation cascade, thereby preventing thrombin generation and blood clot formation.
• Arixtra · Mylan Ireland Ltd · Cardiovascular
  Arixtra works by blocking the action of factor Xa, a protein involved in blood clotting.
• Fondaparinux Sodium (Arixtra) · Paul Di Cesare,MD · Cardiovascular
  Fondaparinux selectively inhibits Factor Xa, a key enzyme in the coagulation cascade, preventing thrombin generation and blood clot formation.
• Uninterrupted apixaban · Baim Institute for Clinical Research · Cardiovascular
  Apixaban is a Factor Xa inhibitor that prevents blood clot formation by blocking a key enzyme in the coagulation cascade.
• low-dose rivaroxaban · China National Center for Cardiovascular Diseases · Cardiovascular
  Low-dose rivaroxaban selectively inhibits Factor Xa in the coagulation cascade, reducing thrombin generation and blood clot formation at a lower dose than standard anticoagulation.
• RB · Kim, Seok Jin · Cardiovascular
  Rivaroxaban is an anticoagulant that works by inhibiting Factor Xa.

Phase 3 pipeline (8)

• fondaparinux - UFH not indicated · GlaxoSmithKline · Cardiovascular
  Fondaparinux is a synthetic anticoagulant that selectively inhibits factor Xa.
• Rivaroxaban (BAY59-7939) · Bayer · Cardiovascular
  Rivaroxaban is a direct Factor Xa inhibitor that prevents the coagulation cascade.
• Fondaparinux Injectable Product · Queen Mary University of London · Cardiovascular
  Fondaparinux is a synthetic anticoagulant that selectively inhibits Factor Xa, preventing thrombin generation and blood clot formation.
• Fondaparinux - UFH indicated · GlaxoSmithKline · Cardiovascular
  Fondaparinux selectively inhibits Factor Xa, a key enzyme in the coagulation cascade, preventing thrombin generation and blood clot formation.
• Therapeutic dose anticoagulation · UMC Utrecht · Cardiovascular
  Direct Factor Xa inhibition prevents the coagulation cascade.
• Sefaxersen (RO7434656) · Hoffmann-La Roche · Cardiovascular
  Sefaxersen is a direct Factor Xa inhibitor.
• Placebo: tablet of Rivaroxaban · Bayer · Cardiovascular
  Rivaroxaban is a direct Factor Xa inhibitor that prevents the coagulation cascade.
• ARIXTRA infusion · GlaxoSmithKline · Cardiovascular
  ARIXTRA (fondaparinux) selectively inhibits Factor Xa in the coagulation cascade, preventing thrombin generation and blood clot formation.

Phase 1 pipeline (1)

• Apixaban MR2 · Pfizer · Cardiovascular
  Factor Xa inhibitor