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Prevention of Venous Thromboembolism
Prevention of Venous Thromboembolism is a Anticoagulant Small molecule drug developed by Prof. Stavros Konstantinides, MD. It is currently in Phase 3 development for Prevention of venous thromboembolism in patients undergoing major orthopedic surgery. Also known as: Rivaroxaban, Xarelto, anticoag, Direct oral anticoagulant.
This drug prevents the formation of blood clots in the veins by inhibiting the coagulation cascade.
This drug prevents the formation of blood clots in the veins by inhibiting the coagulation cascade. Used for Prevention of venous thromboembolism in patients undergoing major orthopedic surgery.
At a glance
| Generic name | Prevention of Venous Thromboembolism |
|---|---|
| Also known as | Rivaroxaban, Xarelto, anticoag, Direct oral anticoagulant, DOAC |
| Sponsor | Prof. Stavros Konstantinides, MD |
| Drug class | Anticoagulant |
| Target | Factor Xa |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
It does this by targeting and inhibiting the activity of Factor Xa, a key enzyme in the coagulation pathway. This leads to a reduction in the formation of thrombin, which is essential for blood clot formation. As a result, the risk of venous thromboembolism is decreased.
Approved indications
- Prevention of venous thromboembolism in patients undergoing major orthopedic surgery
Common side effects
- Major bleeding
- Gastrointestinal bleeding
- Hemorrhage
Key clinical trials
- Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants With Solid and Hematologic Cancers (PHASE3)
- Timing of Venous Thromboembolism Prophylaxis in Patients With Hypertensive Intracerebral Hemorrhage (NA)
- AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positive Myeloproliferative Neoplasms (PHASE3)
- REGN7508 in Adult Participants for Prevention of Cancer-Associated Thrombosis (PHASE3)
- REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants (PHASE3)
- Utilizing Anti-Factor Xa as a Predictive Tool for Optimizing Outcome in Burn Patients' Management (NA)
- A Clinical Study of SHR-2004 Injection in Preventing Venous Thromboembolism in Patients Undergoing Total Knee Arthroplasty (PHASE3)
- REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Prevention of Venous Thromboembolism CI brief — competitive landscape report
- Prevention of Venous Thromboembolism updates RSS · CI watch RSS
- Prof. Stavros Konstantinides, MD portfolio CI
Frequently asked questions about Prevention of Venous Thromboembolism
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Related
- Drug class: All Anticoagulant drugs
- Target: All drugs targeting Factor Xa
- Manufacturer: Prof. Stavros Konstantinides, MD — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Prevention of venous thromboembolism in patients undergoing major orthopedic surgery
- Also known as: Rivaroxaban, Xarelto, anticoag, Direct oral anticoagulant, DOAC
- Compare: Prevention of Venous Thromboembolism vs similar drugs
- Pricing: Prevention of Venous Thromboembolism cost, discount & access