Dihydropteroate synthase and dihydrofolate reductase — Drug Target

All drugs that target Dihydropteroate synthase and dihydrofolate reductase — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Sulfonamide antibiotic combination · Sulfonamide + dihydrofolate reductase inhibitor combination · Antifolate antimalarial combination

Marketed (5)

• Co-trimoxazole 20 · Khon Kaen University · Sulfonamide antibiotic combination · Infectious Disease
  Co-trimoxazole is a fixed-dose combination of sulfamethoxazole and trimethoprim that inhibits bacterial folate synthesis at two sequential steps, preventing DNA replication.
• Trimethoprim and sulfamethoxazole · National Institute of Allergy and Infectious Diseases (NIAID) · Sulfonamide antibiotic combination · Infectious Disease
  Trimethoprim and sulfamethoxazole is a fixed-dose combination antibiotic that inhibits bacterial folate synthesis by blocking two sequential enzymes in the pathway.
• Sulfamethoxazole / Trimethoprim Injectable Product · Fundacion Clinic per a la Recerca Biomédica · Sulfonamide + dihydrofolate reductase inhibitor combination · Infectious Disease
  Sulfamethoxazole and trimethoprim are synergistic antibiotics that inhibit bacterial folate synthesis by blocking dihydropteroate synthase and dihydrofolate reductase, respectively.
• Co-trimoxazole 12 · Khon Kaen University · Sulfonamide antibiotic combination · Infectious Disease
  Co-trimoxazole is a fixed-dose combination of sulfamethoxazole and trimethoprim that inhibits bacterial folate synthesis at two sequential steps, preventing DNA replication.
• Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] · Fundacion Clinic per a la Recerca Biomédica · Sulfonamide antibiotic combination · Infectious Disease
  Sulfamethoxazole and trimethoprim are synergistic antibiotics that inhibit bacterial folate synthesis by blocking dihydropteroate synthase and dihydrofolate reductase, respectively.

Phase 3 pipeline (2)

• Cotrimoxazole dispersible tablet · University of Oxford · Sulfonamide antibiotic combination · Infectious Disease
  Cotrimoxazole is a fixed-dose combination of sulfamethoxazole and trimethoprim that inhibits bacterial folate synthesis at two sequential steps, preventing DNA replication.
• Intermittent preventive treatment:sulphadoxine-pyrimethamine · London School of Hygiene and Tropical Medicine · Antifolate antimalarial combination · Infectious Disease
  Sulphadoxine-pyrimethamine is a fixed-dose antimalarial combination that inhibits folate synthesis in Plasmodium parasites, preventing malaria infection when given intermittently as preventive treatment.