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Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim]

Fundacion Clinic per a la Recerca Biomédica · FDA-approved active Small molecule

Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] is a Sulfonamide antibiotic combination Small molecule drug developed by Fundacion Clinic per a la Recerca Biomédica. It is currently FDA-approved for Urinary tract infections, Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment, Acute otitis media.

Sulfamethoxazole and trimethoprim are synergistic antibiotics that inhibit bacterial folate synthesis by blocking dihydropteroate synthase and dihydrofolate reductase, respectively.

Sulfamethoxazole and trimethoprim are synergistic antibiotics that inhibit bacterial folate synthesis by blocking dihydropteroate synthase and dihydrofolate reductase, respectively. Used for Urinary tract infections, Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment, Acute otitis media.

At a glance

Generic nameSulfamethoxazole / Trimethoprim Oral Tablet [Bactrim]
SponsorFundacion Clinic per a la Recerca Biomédica
Drug classSulfonamide antibiotic combination
TargetDihydropteroate synthase and dihydrofolate reductase
ModalitySmall molecule
Therapeutic areaInfectious Disease
PhaseFDA-approved

Mechanism of action

Sulfamethoxazole is a sulfonamide that inhibits dihydropteroate synthase, preventing the formation of dihydrofolate from para-aminobenzoic acid. Trimethoprim inhibits dihydrofolate reductase, blocking the conversion of dihydrofolate to tetrahydrofolate. Together, they create a sequential blockade of bacterial folate metabolism, which is essential for nucleotide synthesis and bacterial DNA replication.

Approved indications

Common side effects

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Frequently asked questions about Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim]

What is Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim]?

Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] is a Sulfonamide antibiotic combination drug developed by Fundacion Clinic per a la Recerca Biomédica, indicated for Urinary tract infections, Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment, Acute otitis media.

How does Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] work?

Sulfamethoxazole and trimethoprim are synergistic antibiotics that inhibit bacterial folate synthesis by blocking dihydropteroate synthase and dihydrofolate reductase, respectively.

What is Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] used for?

Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] is indicated for Urinary tract infections, Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment, Acute otitis media, Traveler's diarrhea, Toxoplasmosis.

Who makes Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim]?

Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] is developed and marketed by Fundacion Clinic per a la Recerca Biomédica (see full Fundacion Clinic per a la Recerca Biomédica pipeline at /company/fundacion-clinic-per-a-la-recerca-biom-dica).

What drug class is Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] in?

Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] belongs to the Sulfonamide antibiotic combination class. See all Sulfonamide antibiotic combination drugs at /class/sulfonamide-antibiotic-combination.

What development phase is Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] in?

Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] is FDA-approved (marketed).

What are the side effects of Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim]?

Common side effects of Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] include Rash, Nausea, Vomiting, Diarrhea, Hyperkalemia, Stevens-Johnson syndrome.

What does Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] target?

Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] targets Dihydropteroate synthase and dihydrofolate reductase and is a Sulfonamide antibiotic combination.

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