{"id":"sulfamethoxazole-trimethoprim-oral-tablet-bactrim","safety":{"commonSideEffects":[{"rate":"3-6","effect":"Rash"},{"rate":"3-8","effect":"Nausea"},{"rate":"2-5","effect":"Vomiting"},{"rate":"2-5","effect":"Diarrhea"},{"rate":"1-3","effect":"Hyperkalemia"},{"rate":null,"effect":"Stevens-Johnson syndrome"},{"rate":null,"effect":"Hepatotoxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sulfamethoxazole is a sulfonamide that inhibits dihydropteroate synthase, preventing the formation of dihydrofolate from para-aminobenzoic acid. Trimethoprim inhibits dihydrofolate reductase, blocking the conversion of dihydrofolate to tetrahydrofolate. Together, they create a sequential blockade of bacterial folate metabolism, which is essential for nucleotide synthesis and bacterial DNA replication.","oneSentence":"Sulfamethoxazole and trimethoprim are synergistic antibiotics that inhibit bacterial folate synthesis by blocking dihydropteroate synthase and dihydrofolate reductase, respectively.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:10:11.410Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Urinary tract infections"},{"name":"Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment"},{"name":"Acute otitis media"},{"name":"Traveler's diarrhea"},{"name":"Toxoplasmosis"},{"name":"Bacterial infections susceptible to the combination"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim]","genericName":"Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim]","companyName":"Fundacion Clinic per a la Recerca Biomédica","companyId":"fundacion-clinic-per-a-la-recerca-biom-dica","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sulfamethoxazole and trimethoprim are synergistic antibiotics that inhibit bacterial folate synthesis by blocking dihydropteroate synthase and dihydrofolate reductase, respectively. Used for Urinary tract infections, Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment, Acute otitis media.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}