Sulfonamide antibiotic combination

This page covers all Sulfonamide antibiotic combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Dihydropteroate synthase and dihydrofolate reductase, Dihydrofolate reductase; dihydropteroate synthase.

Targets

Dihydropteroate synthase and dihydrofolate reductase · Dihydrofolate reductase; dihydropteroate synthase

Marketed (5)

• Trimethoprim and sulfamethoxazole · National Institute of Allergy and Infectious Diseases (NIAID) · Infectious Disease
  Trimethoprim and sulfamethoxazole is a fixed-dose combination antibiotic that inhibits bacterial folate synthesis by blocking two sequential enzymes in the pathway.
• Co-trimoxazole 12 · Khon Kaen University · Infectious Disease
  Co-trimoxazole is a fixed-dose combination of sulfamethoxazole and trimethoprim that inhibits bacterial folate synthesis at two sequential steps, preventing DNA replication.
• TMX-SMX (Bactrim(R)) · Department of Medical Services Ministry of Public Health of Thailand · Infectious Disease
  TMX-SMX (trimethoprim-sulfamethoxazole) is a fixed-dose combination antibiotic that inhibits bacterial folate synthesis by blocking dihydrofolate reductase and dihydropteroate synthase.
• Co-trimoxazole 20 · Khon Kaen University · Infectious Disease
  Co-trimoxazole is a fixed-dose combination of sulfamethoxazole and trimethoprim that inhibits bacterial folate synthesis at two sequential steps, preventing DNA replication.
• Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] · Fundacion Clinic per a la Recerca Biomédica · Infectious Disease
  Sulfamethoxazole and trimethoprim are synergistic antibiotics that inhibit bacterial folate synthesis by blocking dihydropteroate synthase and dihydrofolate reductase, respectively.

Phase 3 pipeline (1)

• Cotrimoxazole dispersible tablet · University of Oxford · Infectious Disease
  Cotrimoxazole is a fixed-dose combination of sulfamethoxazole and trimethoprim that inhibits bacterial folate synthesis at two sequential steps, preventing DNA replication.