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Cotrimoxazole dispersible tablet
Cotrimoxazole dispersible tablet is a Sulfonamide antibiotic combination Small molecule drug developed by University of Oxford. It is currently in Phase 3 development for Bacterial infections (urinary tract infections, respiratory tract infections, otitis media), Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment, Toxoplasmosis. Also known as: Cosatrim, Septrin, Bactrim.
Cotrimoxazole is a fixed-dose combination of sulfamethoxazole and trimethoprim that inhibits bacterial folate synthesis at two sequential steps, preventing DNA replication.
Cotrimoxazole is a fixed-dose combination of sulfamethoxazole and trimethoprim that inhibits bacterial folate synthesis at two sequential steps, preventing DNA replication. Used for Bacterial infections (urinary tract infections, respiratory tract infections, otitis media), Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment, Toxoplasmosis.
At a glance
| Generic name | Cotrimoxazole dispersible tablet |
|---|---|
| Also known as | Cosatrim, Septrin, Bactrim |
| Sponsor | University of Oxford |
| Drug class | Sulfonamide antibiotic combination |
| Target | Dihydropteroate synthase and dihydrofolate reductase |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Sulfamethoxazole inhibits dihydropteroate synthase, while trimethoprim inhibits dihydrofolate reductase. Together, they block the bacterial synthesis of dihydrofolate and tetrahydrofolate, essential cofactors for nucleotide synthesis. This synergistic dual inhibition is bactericidal and provides broad-spectrum coverage against many gram-positive and gram-negative organisms.
Approved indications
- Bacterial infections (urinary tract infections, respiratory tract infections, otitis media)
- Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment
- Toxoplasmosis
Common side effects
- Rash
- Nausea
- Vomiting
- Diarrhea
- Hyperkalemia
- Stevens-Johnson syndrome
Key clinical trials
- Empirical Treatment Against Cytomegalovirus and Tuberculosis in HIV-infected Infants With Severe Pneumonia (PHASE2, PHASE3)
- Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil in Children With Steroid-dependent Nephrotic Syndrome (PHASE2)
- Primary Antibiotic Prophylaxis Using Co-trimoxazole to Prevent Spontaneous Bacterial Peritonitis in Cirrhosis (PHASE3)
- Cotrimoxazole Prophylaxis in Severely Malnourished Children (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Cotrimoxazole dispersible tablet CI brief — competitive landscape report
- Cotrimoxazole dispersible tablet updates RSS · CI watch RSS
- University of Oxford portfolio CI
Frequently asked questions about Cotrimoxazole dispersible tablet
What is Cotrimoxazole dispersible tablet?
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Related
- Drug class: All Sulfonamide antibiotic combination drugs
- Target: All drugs targeting Dihydropteroate synthase and dihydrofolate reductase
- Manufacturer: University of Oxford — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Bacterial infections (urinary tract infections, respiratory tract infections, otitis media)
- Indication: Drugs for Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment
- Indication: Drugs for Toxoplasmosis
- Also known as: Cosatrim, Septrin, Bactrim
- Compare: Cotrimoxazole dispersible tablet vs similar drugs
- Pricing: Cotrimoxazole dispersible tablet cost, discount & access