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Intermittent preventive treatment:sulphadoxine-pyrimethamine
Intermittent preventive treatment:sulphadoxine-pyrimethamine is a Antifolate antimalarial combination Small molecule drug developed by London School of Hygiene and Tropical Medicine. It is currently in Phase 3 development for Intermittent preventive treatment of malaria in pregnant women, Intermittent preventive treatment of malaria in infants.
Sulphadoxine-pyrimethamine is a fixed-dose antimalarial combination that inhibits folate synthesis in Plasmodium parasites, preventing malaria infection when given intermittently as preventive treatment.
Sulphadoxine-pyrimethamine is a fixed-dose antimalarial combination that inhibits folate synthesis in Plasmodium parasites, preventing malaria infection when given intermittently as preventive treatment. Used for Intermittent preventive treatment of malaria in pregnant women, Intermittent preventive treatment of malaria in infants.
At a glance
| Generic name | Intermittent preventive treatment:sulphadoxine-pyrimethamine |
|---|---|
| Sponsor | London School of Hygiene and Tropical Medicine |
| Drug class | Antifolate antimalarial combination |
| Target | Dihydropteroate synthase and dihydrofolate reductase |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Sulphadoxine and pyrimethamine are antifolate agents that sequentially block dihydropteroate synthase and dihydrofolate reductase in the parasite's folate metabolism pathway. This dual inhibition prevents DNA synthesis and replication in Plasmodium species. Intermittent preventive treatment (IPT) involves periodic dosing to maintain protective drug levels and prevent malaria parasitemia in at-risk populations, particularly pregnant women and infants in endemic areas.
Approved indications
- Intermittent preventive treatment of malaria in pregnant women
- Intermittent preventive treatment of malaria in infants
Common side effects
- Gastrointestinal disturbances
- Rash
- Folate deficiency
- Allergic reactions
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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Related
- Drug class: All Antifolate antimalarial combination drugs
- Target: All drugs targeting Dihydropteroate synthase and dihydrofolate reductase
- Manufacturer: London School of Hygiene and Tropical Medicine — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Intermittent preventive treatment of malaria in pregnant women
- Indication: Drugs for Intermittent preventive treatment of malaria in infants
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