The Efficacy and Cost-effectiveness of Malaria Prevention in Pregnancy in an Area of Low and Unstable Transmission in Kabale, Uganda: Use of Intermittent Preventive Treatment and Insecticide-treated Nets.

NCT00142207 Phase 3 COMPLETED

The purpose of this study is to compare the efficacy and cost-effectiveness of three alternative strategies for the prevention of malaria during pregnancy in an epidemic-prone area of low transmission in the East African Highlands. The strategies being compared are: * intermittent preventive treatment with sulfadoxine-pyrimethamine (IPT-SP) * an insecticide treated net (ITN), and * intermittent preventive treatment with SP plus an ITN In addition to the main individually-randomised trial, outcome data was subsequently also gathered on pregnant women whose houses where sprayed with indoor residual insecticides (IRS) as part of a non-randomised district-wide control programme to compare the impact of IRS with the three intervention arms.

Details

Lead sponsor	London School of Hygiene and Tropical Medicine
Phase	Phase 3
Status	COMPLETED
Enrolment	4775
Start date	2004-01
Completion	2007-01

Conditions

• Malaria, Falciparum

Interventions

• Intermittent preventive treatment:sulphadoxine-pyrimethamine
• Insecticide-treated mosquito bed net

Primary outcomes

• mean birthweight — April 2004-Jan 2007
• prevalence of low birthweight — April 2004 - Jan 2007

Countries

Uganda