{"id":"intermittent-preventive-treatment-sulphadoxine-pyrimethamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Folate deficiency"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sulphadoxine and pyrimethamine are antifolate agents that sequentially block dihydropteroate synthase and dihydrofolate reductase in the parasite's folate metabolism pathway. This dual inhibition prevents DNA synthesis and replication in Plasmodium species. Intermittent preventive treatment (IPT) involves periodic dosing to maintain protective drug levels and prevent malaria parasitemia in at-risk populations, particularly pregnant women and infants in endemic areas.","oneSentence":"Sulphadoxine-pyrimethamine is a fixed-dose antimalarial combination that inhibits folate synthesis in Plasmodium parasites, preventing malaria infection when given intermittently as preventive treatment.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:39.012Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intermittent preventive treatment of malaria in pregnant women"},{"name":"Intermittent preventive treatment of malaria in infants"}]},"trialDetails":[{"nctId":"NCT00142207","phase":"PHASE3","title":"Preventing Malaria During Pregnancy in Epidemic-prone Areas.","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2004-01","conditions":"Malaria, Falciparum","enrollment":4775}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Intermittent preventive treatment:sulphadoxine-pyrimethamine","genericName":"Intermittent preventive treatment:sulphadoxine-pyrimethamine","companyName":"London School of Hygiene and Tropical Medicine","companyId":"london-school-of-hygiene-and-tropical-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sulphadoxine-pyrimethamine is a fixed-dose antimalarial combination that inhibits folate synthesis in Plasmodium parasites, preventing malaria infection when given intermittently as preventive treatment. Used for Intermittent preventive treatment of malaria in pregnant women, Intermittent preventive treatment of malaria in infants.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}