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Intermittent preventive treatment:sulphadoxine-pyrimethamine — Competitive Intelligence Brief

Intermittent preventive treatment:sulphadoxine-pyrimethamine (Intermittent preventive treatment:sulphadoxine-pyrimethamine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antifolate antimalarial combination. Area: Infectious Disease.

phase 3 Antifolate antimalarial combination Dihydropteroate synthase and dihydrofolate reductase Infectious Disease Small molecule Live · refreshed every 30 min

Target snapshot

Intermittent preventive treatment:sulphadoxine-pyrimethamine (Intermittent preventive treatment:sulphadoxine-pyrimethamine) — London School of Hygiene and Tropical Medicine. Sulphadoxine-pyrimethamine is a fixed-dose antimalarial combination that inhibits folate synthesis in Plasmodium parasites, preventing malaria infection when given intermittently as preventive treatment.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

DrugGenericSponsorPhaseClassTargetApproval / PDUFA
Intermittent preventive treatment:sulphadoxine-pyrimethamine TARGET Intermittent preventive treatment:sulphadoxine-pyrimethamine London School of Hygiene and Tropical Medicine phase 3 Antifolate antimalarial combination Dihydropteroate synthase and dihydrofolate reductase
Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim] Fundacion Clinic per a la Recerca Biomédica marketed Sulfonamide antibiotic combination Dihydropteroate synthase and dihydrofolate reductase
Co-trimoxazole 20 Co-trimoxazole 20 Khon Kaen University marketed Sulfonamide antibiotic combination Dihydropteroate synthase and dihydrofolate reductase
Sulfamethoxazole / Trimethoprim Injectable Product Sulfamethoxazole / Trimethoprim Injectable Product Fundacion Clinic per a la Recerca Biomédica marketed Sulfonamide + dihydrofolate reductase inhibitor combination Dihydropteroate synthase and dihydrofolate reductase
Co-trimoxazole 12 Co-trimoxazole 12 Khon Kaen University marketed Sulfonamide antibiotic combination Dihydropteroate synthase and dihydrofolate reductase
Trimethoprim and sulfamethoxazole Trimethoprim and sulfamethoxazole National Institute of Allergy and Infectious Diseases (NIAID) marketed Sulfonamide antibiotic combination Dihydropteroate synthase and dihydrofolate reductase
Cotrimoxazole dispersible tablet Cotrimoxazole dispersible tablet University of Oxford phase 3 Sulfonamide antibiotic combination Dihydropteroate synthase and dihydrofolate reductase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antifolate antimalarial combination class)

  1. London School of Hygiene and Tropical Medicine · 4 drugs in this class
  2. Kenya Medical Research Institute · 1 drug in this class
  3. Swiss Tropical & Public Health Institute · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Intermittent preventive treatment:sulphadoxine-pyrimethamine — Competitive Intelligence Brief. https://druglandscape.com/ci/intermittent-preventive-treatment-sulphadoxine-pyrimethamine. Accessed 2026-05-18.

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