What are Antifolate antimalarial combination drugs?

Antifolate antimalarial combination drugs are pharmacologic agents that share a common mechanism (typically targeting Dihydrofolate reductase (DHFR)). 1 are currently marketed, with 5 more in clinical development.

What are the marketed Antifolate antimalarial combination drugs?

Marketed Antifolate antimalarial combination drugs include IPTp-SP.

Antifolate antimalarial combination

1 marketed 5 in Phase 3

This page covers all Antifolate antimalarial combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Dihydrofolate reductase (DHFR), Dihydrofolate reductase (pyrimethamine); dihydropteroate synthase (sulfadoxine), Dihydrofolate reductase; Dihydropteroate synthase.

Targets

Dihydrofolate reductase (DHFR) · Dihydrofolate reductase (pyrimethamine); dihydropteroate synthase (sulfadoxine) · Dihydrofolate reductase; Dihydropteroate synthase · Dihydropteroate synthase and dihydrofolate reductase · Dihydrofolate reductase; dihydropteroate synthase · Dihydropteroate synthase; Dihydrofolate reductase

Marketed (1)

IPTp-SP · Kenya Medical Research Institute · Infectious Disease / Parasitology
IPTp-SP is a combination of intermittent preventive treatment using sulfadoxine-pyrimethamine to prevent malaria infection in pregnant women by inhibiting folate synthesis in the malaria parasite.

Phase 3 pipeline (5)

Pyrimethamine/sulfadoxine · London School of Hygiene and Tropical Medicine · Infectious Disease
Pyrimethamine and sulfadoxine work together to inhibit folate metabolism in malaria parasites, blocking nucleotide synthesis and parasite replication.
IPTp-sulphadoxine-pyrimethamine · London School of Hygiene and Tropical Medicine · Infectious Disease / Parasitology
Sulphadoxine-pyrimethamine is an antimalarial combination that inhibits dihydrofolate reductase and dihydropteroate synthase, blocking folate synthesis in Plasmodium parasites.
Intermittent preventive treatment:sulphadoxine-pyrimethamine · London School of Hygiene and Tropical Medicine · Infectious Disease
Sulphadoxine-pyrimethamine is a fixed-dose antimalarial combination that inhibits folate synthesis in Plasmodium parasites, preventing malaria infection when given intermittently as preventive treatment.
sulfadoxine-pyrimethamine and chlorproguanil-dapsone · London School of Hygiene and Tropical Medicine · Infectious Disease
This combination of two antimalarial drugs works by inhibiting folate synthesis in Plasmodium parasites, preventing DNA replication and parasite growth.
Sulfadoxine-pyrimethamine used for IPTi · Swiss Tropical & Public Health Institute · Infectious Disease
Sulfadoxine-pyrimethamine is a fixed-dose combination of two antifolate drugs that inhibits dihydrofolate reductase and dihydropteroate synthase, blocking folate synthesis in malaria parasites.