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sulfadoxine-pyrimethamine and chlorproguanil-dapsone
sulfadoxine-pyrimethamine and chlorproguanil-dapsone is a Antifolate antimalarial combination Small molecule drug developed by London School of Hygiene and Tropical Medicine. It is currently in Phase 3 development for Malaria treatment and prevention, Plasmodium falciparum malaria in areas with drug resistance.
This combination of two antimalarial drugs works by inhibiting folate synthesis in Plasmodium parasites, preventing DNA replication and parasite growth.
This combination of two antimalarial drugs works by inhibiting folate synthesis in Plasmodium parasites, preventing DNA replication and parasite growth. Used for Malaria treatment and prevention, Plasmodium falciparum malaria in areas with drug resistance.
At a glance
| Generic name | sulfadoxine-pyrimethamine and chlorproguanil-dapsone |
|---|---|
| Sponsor | London School of Hygiene and Tropical Medicine |
| Drug class | Antifolate antimalarial combination |
| Target | Dihydrofolate reductase; dihydropteroate synthase |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Sulfadoxine-pyrimethamine (SP) and chlorproguanil-dapsone (CD) are both antifolate combinations that target sequential steps in the parasite's folate metabolism pathway. Sulfadoxine inhibits dihydropteroate synthase while pyrimethamine inhibits dihydrofolate reductase; similarly, chlorproguanil inhibits dihydrofolate reductase and dapsone inhibits dihydropteroate synthase. This dual mechanism reduces the likelihood of resistance development compared to monotherapy.
Approved indications
- Malaria treatment and prevention
- Plasmodium falciparum malaria in areas with drug resistance
Common side effects
- Gastrointestinal disturbances (nausea, vomiting, diarrhea)
- Rash
- Hemolytic anemia (particularly in G6PD-deficient individuals)
- Headache
Key clinical trials
- IPT and Efficacy of Sulphadoxine/Pyrimethamine and Chlorproguanil/Dapsone in 6-59 Month Old Children With Malaria. (PHASE3)
- Kilimanjaro IPTi Drug Options Trial (PHASE2, PHASE3)
- Chlorproguanil/Dapsone Compared With Chloroquine and SP for Vivax Malaria (PHASE3)
- Intermittent Preventive Treatment With Antimalarials in Kenyan Infants (NA)
- Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi (PHASE4)
- Tolerability and Efficacy of CD+A Compared to AQ+SP for the Treatment of P.Falciparum Malaria in Rwandan Children (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- sulfadoxine-pyrimethamine and chlorproguanil-dapsone CI brief — competitive landscape report
- sulfadoxine-pyrimethamine and chlorproguanil-dapsone updates RSS · CI watch RSS
- London School of Hygiene and Tropical Medicine portfolio CI
Frequently asked questions about sulfadoxine-pyrimethamine and chlorproguanil-dapsone
What is sulfadoxine-pyrimethamine and chlorproguanil-dapsone?
How does sulfadoxine-pyrimethamine and chlorproguanil-dapsone work?
What is sulfadoxine-pyrimethamine and chlorproguanil-dapsone used for?
Who makes sulfadoxine-pyrimethamine and chlorproguanil-dapsone?
What drug class is sulfadoxine-pyrimethamine and chlorproguanil-dapsone in?
What development phase is sulfadoxine-pyrimethamine and chlorproguanil-dapsone in?
What are the side effects of sulfadoxine-pyrimethamine and chlorproguanil-dapsone?
What does sulfadoxine-pyrimethamine and chlorproguanil-dapsone target?
Related
- Drug class: All Antifolate antimalarial combination drugs
- Target: All drugs targeting Dihydrofolate reductase; dihydropteroate synthase
- Manufacturer: London School of Hygiene and Tropical Medicine — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Malaria treatment and prevention
- Indication: Drugs for Plasmodium falciparum malaria in areas with drug resistance
- Compare: sulfadoxine-pyrimethamine and chlorproguanil-dapsone vs similar drugs
- Pricing: sulfadoxine-pyrimethamine and chlorproguanil-dapsone cost, discount & access