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Open Study on the Tolerability and Efficacy of the Combination Chlorproguanil-Dapsone+Artesunate Compared to Amodiaquine+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria in Rwandan Children
In 2005-2006, a clinical trial was carried out to test safety, tolerability and efficacy of the combination chlorproguanil-dapsone+artesunate (CD+A): 800 children aged 12-59 months with uncomplicated P. falciparum malaria randomly allocated to AQ+SP or CD+A were followed up until day 28 after treatment. Adverse events, clinical and parasitological outcomes were recorded.
Details
| Lead sponsor | London School of Hygiene and Tropical Medicine |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 800 |
| Start date | 2005-04 |
| Completion | 2006-10 |
Conditions
- Malaria
Interventions
- Chlorproguanil-dapsone + artesunate
Primary outcomes
- Incidence of microscopically and genotypically confirmed recrudescent infections in the different treatment groups by day 28
Countries
Rwanda