Bacterial 30S ribosomal subunit — Drug Target

All drugs that target Bacterial 30S ribosomal subunit — marketed and clinical-stage. Includes 2 drug classes acting on this target.

Drug classes

Tetracycline antibiotic · Aminoglycoside antibiotic

Marketed (26)

• Tetracyclin ointment · University of Oslo · Tetracycline antibiotic · Infectious Disease / Dermatology
  Tetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing peptide bond formation and bacterial growth.
• Tobramycin Inhalant Product · Shanghai Pulmonary Hospital, Shanghai, China · Aminoglycoside antibiotic · Infectious Disease / Pulmonology
  Tobramycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to bactericidal activity against aerobic gram-negative and some gram-positive bacteria.
• Minocycline (yes/no) · Medical University of South Carolina · Tetracycline antibiotic · Infectious Disease
  Minocycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
• Treatment with Amikacin · Assistance Publique Hopitaux De Marseille · Aminoglycoside antibiotic · Infectious Disease
  Amikacin is an aminoglycoside antibiotic that binds to bacterial 30S ribosomal subunits and inhibits protein synthesis, leading to bacterial cell death.
• Minocycline HCl · OraPharma · Tetracycline antibiotic · Infectious Disease; Dermatology; Periodontal Disease
  Minocycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
• Gentamicin - three days · Murdoch Childrens Research Institute · Aminoglycoside antibiotic · Infectious Disease
  Gentamicin is an aminoglycoside antibiotic that binds to bacterial ribosomes and inhibits protein synthesis, leading to bacterial cell death.
• inhaled tobramycin · Seattle Children's Hospital · Aminoglycoside antibiotic · Infectious Disease / Pulmonology
  Tobramycin is an aminoglycoside antibiotic that binds to bacterial ribosomes and inhibits protein synthesis, killing susceptible bacteria in the lungs.
• Usual doses of tigecycline · Air Force Specialized Hospital, Cairo, Egypt · Tetracycline antibiotic · Infectious Disease
  Tigecycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing peptide elongation.
• Doxycycline Hyclate Enteric-Coated Capsules · The Third Xiangya Hospital of Central South University · Tetracycline antibiotic · Infectious Disease
  Doxycycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
• Tetracycline Pill · National Cheng-Kung University Hospital · Tetracycline antibiotic · Infectious Disease
  Tetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing peptide bond formation.
• Amikacin (Inhalation) · The University of Queensland · Aminoglycoside antibiotic · Infectious Disease
  Amikacin is an aminoglycoside antibiotic that binds to bacterial ribosomes and inhibits protein synthesis, leading to bacterial cell death.
• hand mixed tobramycin · Washington University School of Medicine · Aminoglycoside antibiotic · Infectious Disease
  Tobramycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
• tetracycline (BQ10) · National Taiwan University Hospital · Tetracycline antibiotic · Infectious Disease
  Tetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing peptide bond formation.
• Bethkis® · Mylan Inc. · Aminoglycoside antibiotic · Infectious Disease / Pulmonary
  Bethkis is an inhaled antibiotic that delivers tobramycin directly to the lungs to kill Pseudomonas aeruginosa bacteria in cystic fibrosis patients.
• Minocycline vs Lymecycline · Darier · Tetracycline antibiotic · Dermatology / Infectious Disease
  Both minocycline and lymecycline are tetracycline antibiotics that inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit.
• Oral doxycycline hyclate · Galderma R&D · Tetracycline antibiotic · Infectious Disease
  Doxycycline hyclate is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
• Omadacycline Injection · Wake Forest University Health Sciences · Tetracycline antibiotic · Infectious Disease
  Omadacycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the ribosome.
• Tobramycin once a day · Oslo University Hospital · Aminoglycoside antibiotic · Infectious Disease
  Tobramycin is an aminoglycoside antibiotic that binds to bacterial 30S ribosomal subunits and inhibits protein synthesis, leading to bacterial cell death.
• DoxyPEP · Chinese University of Hong Kong · Tetracycline antibiotic · Infectious Disease / Sexual Health
  DoxyPEP is doxycycline used as a post-exposure prophylaxis to prevent sexually transmitted infections by inhibiting bacterial protein synthesis.
• Amikacin Injection · Murdoch Childrens Research Institute · Aminoglycoside antibiotic · Infectious Disease
  Amikacin is an aminoglycoside antibiotic that binds to bacterial 30S ribosomal subunits and inhibits protein synthesis, leading to bacterial cell death.
• Doxycycline Tablets · Yaounde Central Hospital · Tetracycline antibiotic · Infectious Disease
  Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing peptide bond formation and bacterial growth.
• topical tetracycline · Johns Hopkins University · Tetracycline antibiotic · Dermatology / Infectious Disease
  Topical tetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, reducing microbial growth on the skin surface.
• Doxycycline post-exposure prophylaxis · University of Washington · Tetracycline antibiotic · Infectious Disease
  Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing pathogenic bacteria from multiplying after potential exposure.
• Doxycycline pre-operatively · University of Pittsburgh · Tetracycline antibiotic · Infectious Disease / Surgical Prophylaxis
  Doxycycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, and when used pre-operatively, reduces surgical site infection risk through antimicrobial prophylaxis.
• Neomycin Oral Product · South Australian Health and Medical Research Institute · Aminoglycoside antibiotic · Infectious Disease
  Neomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
• Tigecycline antimicrobial-lock solution · Clinica Universidad de Navarra, Universidad de Navarra · Tetracycline antibiotic · Infectious Disease
  Tigecycline is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing peptide bond formation.

Phase 3 pipeline (8)

• Experimental: doxycycline · ANRS, Emerging Infectious Diseases · Tetracycline antibiotic · Infectious Diseases
  Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing peptide bond formation.
• Systemic Doxycycline and Sham aPDT · University of Sao Paulo · Tetracycline antibiotic · Infectious Disease / Periodontal Disease
  Doxycycline is a broad-spectrum tetracycline antibiotic that inhibits bacterial protein synthesis and possesses anti-inflammatory properties; when combined with sham aPDT (antimicrobial photodynamic therapy), it is being evaluated for its potential antimicrobial and immunomodulatory effects.
• Minocycline hydrochloride capsules · Beijing Tiantan Hospital · Tetracycline antibiotic · Infectious Disease
  Minocycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
• Paromomycin Alone topical cream · U.S. Army Medical Research and Development Command · Aminoglycoside antibiotic · Dermatology / Infectious Disease
  Paromomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, and when applied topically as a cream, it kills or inhibits the growth of susceptible microorganisms on the skin surface.
• Gentamicin Sulfate, Injectable · Public Health Service of Amsterdam · Aminoglycoside antibiotic · Infectious Disease
  Gentamicin sulfate is an aminoglycoside antibiotic that binds to bacterial 30S ribosomal subunits and inhibits protein synthesis, leading to bacterial cell death.
• Paromomycin Sulfate Powder · University of Leipzig · Aminoglycoside antibiotic · Infectious Disease
  Paromomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
• Axillary lavage with gentamicin solution · Hospital General Universitario Elche · Aminoglycoside antibiotic · Infectious Disease / Surgical Prophylaxis
  Gentamicin solution delivered via axillary lavage provides local antibiotic irrigation to reduce bacterial contamination and infection risk in the axillary region during surgical procedures.
• Irrigation with gentamicin solution · Hospital General Universitario Elche · Aminoglycoside antibiotic · Infectious Disease / Surgery
  Gentamicin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to bactericidal activity against gram-negative and some gram-positive organisms.