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Doxycycline pre-operatively

University of Pittsburgh · FDA-approved active Small molecule

Doxycycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, and when used pre-operatively, reduces surgical site infection risk through antimicrobial prophylaxis.

Doxycycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, and when used pre-operatively, reduces surgical site infection risk through antimicrobial prophylaxis. Used for Surgical site infection prophylaxis in pre-operative settings.

At a glance

Generic nameDoxycycline pre-operatively
SponsorUniversity of Pittsburgh
Drug classTetracycline antibiotic
TargetBacterial 30S ribosomal subunit
ModalitySmall molecule
Therapeutic areaInfectious Disease / Surgical Prophylaxis
PhaseFDA-approved

Mechanism of action

Doxycycline prevents bacterial colonization and infection at the surgical site by blocking bacterial protein synthesis. Pre-operative administration achieves adequate tissue concentrations before incision, providing prophylactic coverage against susceptible gram-positive and gram-negative organisms. This reduces post-operative infection rates, particularly in clean-contaminated surgical procedures.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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