{"id":"doxycycline-pre-operatively","safety":{"commonSideEffects":[{"rate":"1-3","effect":"Photosensitivity"},{"rate":"5-10","effect":"Nausea"},{"rate":"1-5","effect":"Esophageal irritation"},{"rate":"1-5","effect":"Vaginal candidiasis"},{"rate":"2-5","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Doxycycline prevents bacterial colonization and infection at the surgical site by blocking bacterial protein synthesis. Pre-operative administration achieves adequate tissue concentrations before incision, providing prophylactic coverage against susceptible gram-positive and gram-negative organisms. This reduces post-operative infection rates, particularly in clean-contaminated surgical procedures.","oneSentence":"Doxycycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, and when used pre-operatively, reduces surgical site infection risk through antimicrobial prophylaxis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:32:30.663Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical site infection prophylaxis in pre-operative settings"}]},"trialDetails":[{"nctId":"NCT00783523","phase":"PHASE1","title":"Influence of MMP on Brain AVM Hemorrhage","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2008-03","conditions":"Arteriovenous Malformations, Cavernous Angiomas, Brain Aneurysms","enrollment":33},{"nctId":"NCT00547170","phase":"PHASE4","title":"Doxycycline Prophylaxis at Vacuum Aspiration Trial","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2007-01","conditions":"Endometritis","enrollment":1000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Doxycycline pre-operatively","genericName":"Doxycycline pre-operatively","companyName":"University of Pittsburgh","companyId":"university-of-pittsburgh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Doxycycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, and when used pre-operatively, reduces surgical site infection risk through antimicrobial prophylaxis. Used for Surgical site infection prophylaxis in pre-operative settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}