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Axillary lavage with gentamicin solution
Gentamicin solution delivered via axillary lavage provides local antibiotic irrigation to reduce bacterial contamination and infection risk in the axillary region during surgical procedures.
Gentamicin solution delivered via axillary lavage provides local antibiotic irrigation to reduce bacterial contamination and infection risk in the axillary region during surgical procedures. Used for Surgical site infection prophylaxis during axillary surgery or procedures.
At a glance
| Generic name | Axillary lavage with gentamicin solution |
|---|---|
| Sponsor | Hospital General Universitario Elche |
| Drug class | Aminoglycoside antibiotic |
| Target | Bacterial 30S ribosomal subunit |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Surgical Prophylaxis |
| Phase | Phase 3 |
Mechanism of action
Gentamicin is an aminoglycoside antibiotic that works by inhibiting bacterial protein synthesis, leading to bactericidal activity against gram-negative and some gram-positive organisms. When used as a lavage solution in the axillary region, it achieves high local concentrations to prevent surgical site infections and reduce microbial burden in the operative field.
Approved indications
- Surgical site infection prophylaxis during axillary surgery or procedures
Common side effects
- Local irritation or inflammation at lavage site
- Nephrotoxicity (with systemic absorption)
- Ototoxicity (with systemic absorption)
Key clinical trials
- Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla (PHASE3)
- Effect of Gentamicin Lavage of the Axillary Surgical Bed After Lymph Node Dissection on Drainage Discharge Volume (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |