{"id":"axillary-lavage-with-gentamicin-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or inflammation at lavage site"},{"rate":null,"effect":"Nephrotoxicity (with systemic absorption)"},{"rate":null,"effect":"Ototoxicity (with systemic absorption)"}]},"_chembl":{"chemblId":"CHEMBL6067485","moleculeType":"Small molecule"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gentamicin is an aminoglycoside antibiotic that works by inhibiting bacterial protein synthesis, leading to bactericidal activity against gram-negative and some gram-positive organisms. When used as a lavage solution in the axillary region, it achieves high local concentrations to prevent surgical site infections and reduce microbial burden in the operative field.","oneSentence":"Gentamicin solution delivered via axillary lavage provides local antibiotic irrigation to reduce bacterial contamination and infection risk in the axillary region during surgical procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:42:15.271Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical site infection prophylaxis during axillary surgery or procedures"}]},"trialDetails":[{"nctId":"NCT02314806","phase":"PHASE3","title":"Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla","status":"COMPLETED","sponsor":"Hospital General Universitario Elche","startDate":"2013-01","conditions":"Breast Cancer","enrollment":51},{"nctId":"NCT01700504","phase":"PHASE3","title":"Effect of Gentamicin Lavage of the Axillary Surgical Bed After Lymph Node Dissection on Drainage Discharge Volume","status":"COMPLETED","sponsor":"Hospital General Universitario Elche","startDate":"2011-05","conditions":"Axillary Drainage Volume After Lymph Node Dissection.","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Axillary lavage with gentamicin solution","genericName":"Axillary lavage with gentamicin solution","companyName":"Hospital General Universitario Elche","companyId":"hospital-general-universitario-elche","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gentamicin solution delivered via axillary lavage provides local antibiotic irrigation to reduce bacterial contamination and infection risk in the axillary region during surgical procedures. Used for Surgical site infection prophylaxis during axillary surgery or procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}