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Tetracycline Pill
Tetracycline Pill is a Tetracycline antibiotic Small molecule drug developed by National Cheng-Kung University Hospital. It is currently FDA-approved for Bacterial infections (respiratory, urinary, skin, and soft tissue infections), Acne vulgaris, Rosacea. Also known as: Tetracycline (250 mg).
Tetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing peptide bond formation.
Tetracycline is a small molecule that inhibits the bacterial 70S ribosome, classified as an inhibitor. It is used to treat various conditions, including Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, and Periodontitis, among others.
At a glance
| Generic name | Tetracycline Pill |
|---|---|
| Also known as | Tetracycline (250 mg) |
| Sponsor | National Cheng-Kung University Hospital |
| Drug class | Tetracycline antibiotic |
| Target | Bacterial 30S ribosomal subunit |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Tetracyclines are broad-spectrum antibiotics that work by blocking the attachment of aminoacyl-tRNA to the bacterial ribosome, thereby halting translation of bacterial proteins. This bacteriostatic mechanism is effective against a wide range of gram-positive and gram-negative bacteria, as well as some atypical organisms like Chlamydia and Mycoplasma. The drug is also used off-label at sub-antimicrobial doses for anti-inflammatory effects in conditions like rosacea and acne.
Approved indications
- Bacterial infections (respiratory, urinary, skin, and soft tissue infections)
- Acne vulgaris
- Rosacea
Common side effects
- Photosensitivity
- Nausea and vomiting
- Esophageal irritation
- Diarrhea
- Vaginal candidiasis
Key clinical trials
- Personalized vs Standard of Care Treatment for Helicobacter Pylori Eradication Among Veterans (PHASE3)
- Parrying the Pitfalls of PrEP: Project PEACH (PHASE4)
- A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression (PHASE4)
- Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEP (EARLY_PHASE1)
- Brain and Stress Study (PHASE4)
- Optimal Duration of Bismuth Quadruple Therapy for Helicobacter Pylori Eradication in Females As Compared with Males (PHASE4)
- Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO) (NA)
- The Efficacy of 10-day and 14-day Bismuth-based Quadruple Therapy in First-line H. Pylori Eradication (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tetracycline Pill CI brief — competitive landscape report
- Tetracycline Pill updates RSS · CI watch RSS
- National Cheng-Kung University Hospital portfolio CI
Frequently asked questions about Tetracycline Pill
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Related
- Drug class: All Tetracycline antibiotic drugs
- Target: All drugs targeting Bacterial 30S ribosomal subunit
- Manufacturer: National Cheng-Kung University Hospital — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Bacterial infections (respiratory, urinary, skin, and soft tissue infections)
- Indication: Drugs for Acne vulgaris
- Indication: Drugs for Rosacea
- Also known as: Tetracycline (250 mg)
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing