Alpha-1 adrenergic receptor — Drug Target
All drugs that target Alpha-1 adrenergic receptor — marketed and clinical-stage. Includes 9 drug classes acting on this target.
Drug classes
Alpha-1 adrenergic receptor agonist · Alpha-blocker · Alpha-1 adrenergic agonist (nasal decongestant) · Alpha-1 adrenergic agonist · Ophthalmic decongestant · Alpha-1 adrenergic receptor antagonist · Sympathomimetic · alpha-blocker · Alpha blocker
Marketed (16)
- Lumify® · Bausch & Lomb Incorporated · Alpha-1 adrenergic receptor agonist · Ophthalmology
Lumify is a selective alpha-1 adrenergic receptor agonist that constricts blood vessels in the eye to reduce redness. - Experimental: Alpha-blocker group · Pedro de Figueiredo Buchalla · Alpha-blocker · Cardiovascular; Urology
Alpha-blockers inhibit alpha-adrenergic receptors on vascular smooth muscle and the prostate, causing vasodilation and reduced urinary obstruction. - Xylometazoline 0,1% · Rigshospitalet, Denmark · Alpha-1 adrenergic agonist (nasal decongestant) · Otolaryngology / Respiratory
Xylometazoline is a selective alpha-1 adrenergic receptor agonist that causes vasoconstriction of nasal blood vessels, reducing nasal congestion. - Oxymetazoline HCL Cream 1.0% · Allergan · Alpha-1 adrenergic agonist · Dermatology
Oxymetazoline is an alpha-1 adrenergic agonist that causes vasoconstriction of blood vessels in the skin, reducing redness and flushing. - Visine® for Contacts® · Merck Sharp & Dohme LLC · Ophthalmic decongestant · Ophthalmology
Visine for Contacts is a decongestant eye drop that constricts blood vessels in the eye to reduce redness and irritation. - Phenylephrine bolus 50 micrograms · Rawalpindi Medical College · Alpha-1 adrenergic agonist · Cardiovascular
Phenylephrine is an alpha-1 adrenergic agonist that causes vasoconstriction and increases blood pressure by stimulating alpha-1 receptors on vascular smooth muscle. - eye drops (Phenylephrin) · Medical University of Graz · Alpha-1 adrenergic agonist · Ophthalmology
Phenylephrine is an alpha-1 adrenergic agonist that constricts blood vessels in the eye to reduce redness and dilate the pupil. - Doxazosin mysylate GITS · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. · Alpha-1 adrenergic receptor antagonist · Cardiovascular; Urology
Doxazosin is an alpha-1 adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow, and also dilates blood vessels to lower blood pressure. - Oxymetazoline 0.05% w/v · Brian J Lipworth · Alpha-1 adrenergic agonist (nasal decongestant) · Otolaryngology / Respiratory
Oxymetazoline is an alpha-1 adrenergic agonist that constricts blood vessels in the nasal mucosa, reducing nasal congestion. - cardiac output changes with "phenylephrine" · University Tunis El Manar · Alpha-1 adrenergic agonist · Cardiovascular
Phenylephrine is an alpha-1 adrenergic agonist that increases peripheral vascular resistance and blood pressure, which can secondarily affect cardiac output through changes in afterload. - Xylometazoline - intranasal application · Association Asthma, Bulgaria · Alpha-1 adrenergic agonist (nasal decongestant) · Otolaryngology / Respiratory
Xylometazoline is a selective alpha-1 adrenergic receptor agonist that constricts blood vessels in the nasal mucosa, reducing congestion and swelling. - Placebo to Prazosin · Brian J Lipworth · Alpha-1 adrenergic receptor antagonist · Cardiovascular; Urology; Psychiatry (off-label)
Prazosin is an alpha-1 adrenergic receptor antagonist that blocks norepinephrine signaling to reduce blood pressure and improve urinary symptoms. - Doxazosin (drug) · Japan Heart Foundation · Alpha-1 adrenergic receptor antagonist · Cardiovascular; Urology
Doxazosin is an alpha-1 adrenergic receptor antagonist that blocks norepinephrine signaling in blood vessels and the prostate, causing vasodilation and smooth muscle relaxation. - Alpha1 Blocker · Eli Lilly and Company · Alpha-1 adrenergic receptor antagonist · Cardiovascular, Urology
Alpha-1 blockers inhibit alpha-1 adrenergic receptors on vascular smooth muscle and the prostate, causing vasodilation and reduced urinary obstruction. - Midodrine Oral Tablet · Institute of Liver and Biliary Sciences, India · Alpha-1 adrenergic agonist · Cardiovascular
Midodrine is an alpha-1 adrenergic agonist that increases blood pressure by constricting blood vessels. - Doxazosin extended release · University of Arkansas · Alpha-1 adrenergic receptor antagonist · Cardiovascular, Urology
Doxazosin is an alpha-1 adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow, and also dilates blood vessels to lower blood pressure.
Phase 3 pipeline (12)
- Optimized medical BPH treatment · University Hospital, Bordeaux · Alpha-1 adrenergic receptor antagonist · Urology
This drug targets the alpha-1 adrenergic receptor to relax smooth muscle in the prostate. - Silodosin capsules Control Group · Shanghai Huilun Pharmaceutical Co., Ltd. · Alpha-1 adrenergic receptor antagonist · Urology
Silodosin is an alpha-1 adrenergic receptor antagonist. - naphazoline hydrocloride · EMS · Alpha-1 adrenergic agonist · Ophthalmology / Otolaryngology
Naphazoline hydrochloride is an alpha-1 adrenergic agonist that causes vasoconstriction of blood vessels in the eye or nasal passages. - Rhofade Cream, 1% · Actavis Inc. · Alpha-1 adrenergic agonist · Dermatology
Oxymetazoline is an alpha-1 adrenergic agonist that constricts blood vessels in the skin to reduce facial redness and flushing. - noradrenaline and vascular filling · Centre Hospitalier Universitaire, Amiens · Sympathomimetic · Cardiovascular
Noradrenaline increases vascular tone and cardiac contractility by stimulating alpha-1 adrenergic receptors. - alpha-blocker or 5-ARI withdrawal · Gangnam Severance Hospital · alpha-blocker · Urology
Alpha-blockers block alpha-1 adrenergic receptors, causing smooth muscle relaxation and vasodilation. - T.Prazosin · Haffkine Bio-Pharmaceutical Corporation Ltd. · Alpha-1 adrenergic receptor antagonist · Cardiovascular
T.Prazosin is an alpha-1 adrenergic receptor antagonist. - Terazosin (Hytrin) · Hospital Authority, Hong Kong · Alpha-1 adrenergic receptor antagonist · Cardiovascular
Terazosin is an alpha-1 adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck, improving urine flow and reducing symptoms of benign prostatic hyperplasia. - alfuzosin (SL770499) · Sanofi · Alpha-1 adrenergic receptor antagonist · Urology
Alfuzosin is an alpha-1 adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck, improving urine flow. - Midodrine Hydrochloride Tablets · Tehran Heart Center · Alpha-1 adrenergic agonist · Cardiovascular
Midodrine is an alpha-1 adrenergic agonist that increases blood pressure by constricting blood vessels. - Vehicle to Oxymetazoline HCL Cream · Allergan · Alpha-1 adrenergic agonist · Dermatology
Oxymetazoline HCL is a selective alpha-1 adrenergic agonist that constricts blood vessels in the skin to reduce facial redness and erythema. - pr Sandoz Tamsulosin · CHU de Quebec-Universite Laval · Alpha-1 adrenergic receptor antagonist · Urology
Tamsulosin is an alpha-1 adrenergic receptor antagonist that relaxes smooth muscles in the prostate and bladder neck, improving urine flow.
Phase 2 pipeline (2)
- Doxazosin Mesylate, Extended Release · San Francisco Veterans Affairs Medical Center · Alpha-1 adrenergic receptor antagonist · Urology
Doxazosin mesylate is an alpha-1 adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck, improving urine flow and reducing symptoms of benign prostatic hyperplasia. - Alpha blocker-alfuzosin · Assaf-Harofeh Medical Center · Alpha blocker · Urology
Alpha blockers, such as alfuzosin, work by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.