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Phenylephrine bolus 50 micrograms
Phenylephrine is an alpha-1 adrenergic agonist that causes vasoconstriction and increases blood pressure by stimulating alpha-1 receptors on vascular smooth muscle.
Phenylephrine is an alpha-1 adrenergic agonist that causes vasoconstriction and increases blood pressure by stimulating alpha-1 receptors on vascular smooth muscle. Used for Acute hypotension requiring rapid blood pressure support, Perioperative hypotension management.
At a glance
| Generic name | Phenylephrine bolus 50 micrograms |
|---|---|
| Sponsor | Rawalpindi Medical College |
| Drug class | Alpha-1 adrenergic agonist |
| Target | Alpha-1 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Phenylephrine selectively binds to alpha-1 adrenergic receptors on blood vessels, triggering smooth muscle contraction and peripheral vasoconstriction. This results in increased systemic vascular resistance and elevated blood pressure. The 50 microgram bolus formulation is used for acute hemodynamic support in hypotensive states.
Approved indications
- Acute hypotension requiring rapid blood pressure support
- Perioperative hypotension management
Common side effects
- Hypertension
- Reflex bradycardia
- Headache
- Anxiety
- Tremor
Competitive intelligence
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