What are Alpha-1 adrenergic agonist drugs?

Alpha-1 adrenergic agonist drugs are pharmacologic agents that share a common mechanism (typically targeting Alpha-1 adrenergic receptor). 5 are currently marketed, with 4 more in clinical development.

What are the marketed Alpha-1 adrenergic agonist drugs?

Marketed Alpha-1 adrenergic agonist drugs include Oxymetazoline HCL Cream 1.0%, Phenylephrine bolus 50 micrograms, Midodrine Oral Tablet, cardiac output changes with "phenylephrine", eye drops (Phenylephrin).

Alpha-1 adrenergic agonist

5 marketed 4 in Phase 3

This page covers all Alpha-1 adrenergic agonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Alpha-1 adrenergic receptor.

Targets

Alpha-1 adrenergic receptor

Marketed (5)

Oxymetazoline HCL Cream 1.0% · Allergan · Dermatology
Oxymetazoline is an alpha-1 adrenergic agonist that causes vasoconstriction of blood vessels in the skin, reducing redness and flushing.
Phenylephrine bolus 50 micrograms · Rawalpindi Medical College · Cardiovascular
Phenylephrine is an alpha-1 adrenergic agonist that causes vasoconstriction and increases blood pressure by stimulating alpha-1 receptors on vascular smooth muscle.
Midodrine Oral Tablet · Institute of Liver and Biliary Sciences, India · Cardiovascular
Midodrine is an alpha-1 adrenergic agonist that increases blood pressure by constricting blood vessels.
cardiac output changes with "phenylephrine" · University Tunis El Manar · Cardiovascular
Phenylephrine is an alpha-1 adrenergic agonist that increases peripheral vascular resistance and blood pressure, which can secondarily affect cardiac output through changes in afterload.
eye drops (Phenylephrin) · Medical University of Graz · Ophthalmology
Phenylephrine is an alpha-1 adrenergic agonist that constricts blood vessels in the eye to reduce redness and dilate the pupil.

Phase 3 pipeline (4)

Rhofade Cream, 1% · Actavis Inc. · Dermatology
Oxymetazoline is an alpha-1 adrenergic agonist that constricts blood vessels in the skin to reduce facial redness and flushing.
naphazoline hydrocloride · EMS · Ophthalmology / Otolaryngology
Naphazoline hydrochloride is an alpha-1 adrenergic agonist that causes vasoconstriction of blood vessels in the eye or nasal passages.
Midodrine Hydrochloride Tablets · Tehran Heart Center · Cardiovascular
Midodrine is an alpha-1 adrenergic agonist that increases blood pressure by constricting blood vessels.
Vehicle to Oxymetazoline HCL Cream · Allergan · Dermatology
Oxymetazoline HCL is a selective alpha-1 adrenergic agonist that constricts blood vessels in the skin to reduce facial redness and erythema.