Sunnybrook Health Sciences Centre

Quick facts

Marketed products

• Acetylsalicylic Acid (ASA) · Cardiovascular; Pain management; Inflammation
  Acetylsalicylic acid irreversibly inhibits cyclooxygenase (COX) enzymes, reducing the production of prostaglandins and thromboxane to decrease inflammation, pain, and platelet aggregation.
• citalopram (celexa) · Psychiatry / Mental Health
  Citalopram selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain.
• Methoxyflurane, MEOF · Anesthesia, Acute Pain Management
  Methoxyflurane is a volatile halogenated ether anesthetic that depresses the central nervous system to produce anesthesia and analgesia.
• Perflutren lipid microsphere
• Placebo (cornstarch)
  Placebo (cornstarch) has no active pharmacological mechanism and produces therapeutic effects solely through the placebo effect.
• Sevoflurane inhalant product · Anesthesiology
  Sevoflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling.
• ticagrelor + aspirin · Cardiovascular
  Ticagrelor and aspirin work together to prevent blood clots by inhibiting platelet activation and aggregation through different pathways.
• Withania somnifera

Phase 3 pipeline

• Cholinesterase Inhibitor · Neurology
  Cholinesterase inhibitors block the enzyme that breaks down acetylcholine, allowing acetylcholine to accumulate in the synapse and enhance cholinergic neurotransmission.
• hypertonic saline mixed Dextran · Critical Care
  Hypertonic saline mixed Dextran works by increasing blood volume and improving blood flow to vital organs.
• Isoflurane Inhalant Product · Anesthesiology
  Isoflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory neurotransmission and suppressing excitatory pathways, producing unconsciousness and analgesia.
• Magnesium sulfate and then Digoxin · Cardiovascular
  Magnesium sulfate reduces cardiac arrhythmias and electrolyte imbalance, while digoxin increases cardiac contractility and slows atrioventricular conduction.
• modified PENTOCLO (mPENTOCLO) · Infectious Disease
  Modified PENTOCLO is a pentamidine-based compound designed to enhance antimicrobial or antiparasitic activity through structural optimization.
• No tranexamic acid · Hematology / Hemostasis
  Tranexamic acid is an antifibrinolytic agent that inhibits plasminogen activation, reducing fibrin degradation and promoting blood clot stability.
• r-HuEPO · Oncology, Nephrology
  r-HuEPO is a recombinant form of human erythropoietin that stimulates red blood cell production.
• sham mPENTOCLO · Cardiovascular
  Pentosan polysulfate sodium is an anticoagulant that works by inhibiting the coagulation cascade.
• Variation in volume of local anesthetic · Anesthesiology / Pain Management
  This is a clinical trial protocol studying how different volumes of local anesthetic affect clinical outcomes, rather than a drug with a defined molecular mechanism.

Phase 2 pipeline

• Alpha Interferon · Oncology, Infectious Diseases
  Alpha Interferon works by stimulating the body's immune system to fight viral infections and cancer.
• Daily TMZ
• Definity Suspension for Injection · Cardiovascular
  Definity Suspension for Injection is a microbubble ultrasound contrast agent that enhances the visualization of cardiac structures and function.
• Lenalidomide and melphalan
• QBECO
• Y90 Ibritumomab Tiuxetan RIT

Phase 1 pipeline

• Bupivacaine hydrogen chloride , epinephrine
• PERT at discharge
• Plasma HPV
• prostaglandin of the clinician's choice
• Ropivacaine 1%

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Sunnybrook Health Sciences Centre portfolio CI brief
• Sunnybrook Health Sciences Centre pipeline updates RSS