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hypertonic saline mixed Dextran
Hypertonic saline mixed Dextran works by increasing blood volume and improving blood flow to vital organs.
Hypertonic saline mixed Dextran works by increasing blood volume and improving blood flow to vital organs. Used for Treatment of severe dehydration, Treatment of hypovolemic shock.
At a glance
| Generic name | hypertonic saline mixed Dextran |
|---|---|
| Sponsor | Sunnybrook Health Sciences Centre |
| Drug class | Crystalloid solution |
| Modality | Biologic |
| Therapeutic area | Critical Care |
| Phase | Phase 3 |
Mechanism of action
This is achieved through the hypertonic saline component, which increases the concentration of sodium in the blood, and the Dextran component, which helps to expand blood volume and improve blood flow. This can be particularly beneficial in cases of severe dehydration or blood loss.
Approved indications
- Treatment of severe dehydration
- Treatment of hypovolemic shock
Common side effects
- Hypotension
- Cardiac arrhythmias
- Renal failure
Key clinical trials
- The Toronto Prehospital Hypertonic Resuscitation Head Injury and Multi Organ Dysfunction Trial (TOPHR HIT) (PHASE3)
- Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- hypertonic saline mixed Dextran CI brief — competitive landscape report
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- Sunnybrook Health Sciences Centre portfolio CI