{"id":"hypertonic-saline-mixed-dextran","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Hypotension"},{"rate":"5-10%","effect":"Cardiac arrhythmias"},{"rate":"1-5%","effect":"Renal failure"}]},"_chembl":{"chemblId":"CHEMBL1697742","moleculeType":"Oligosaccharide","molecularWeight":"504.44"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This is achieved through the hypertonic saline component, which increases the concentration of sodium in the blood, and the Dextran component, which helps to expand blood volume and improve blood flow. This can be particularly beneficial in cases of severe dehydration or blood loss.","oneSentence":"Hypertonic saline mixed Dextran works by increasing blood volume and improving blood flow to vital organs.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:45:16.366Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of severe dehydration"},{"name":"Treatment of hypovolemic shock"}]},"trialDetails":[{"nctId":"NCT01642524","phase":"PHASE3","title":"The Toronto Prehospital Hypertonic Resuscitation Head Injury and Multi Organ Dysfunction Trial (TOPHR HIT)","status":"COMPLETED","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2004-04","conditions":"Traumatic Brain Injury","enrollment":114},{"nctId":"NCT00878631","phase":"PHASE2, PHASE3","title":"Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2004-09","conditions":"Brain Injuries","enrollment":113}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"hypertonic saline mixed Dextran","genericName":"hypertonic saline mixed Dextran","companyName":"Sunnybrook Health Sciences Centre","companyId":"sunnybrook-health-sciences-centre","modality":"Biologic","firstApprovalDate":"","aiSummary":"Hypertonic saline mixed Dextran works by increasing blood volume and improving blood flow to vital organs. Used for Treatment of severe dehydration, Treatment of hypovolemic shock.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}