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Magnesium sulfate and then Digoxin

Sunnybrook Health Sciences Centre · Phase 3 active Small molecule

Magnesium sulfate and then Digoxin is a Electrolyte supplement and cardiac glycoside combination Small molecule drug developed by Sunnybrook Health Sciences Centre. It is currently in Phase 3 development for Acute arrhythmias with hypomagnesemia, Heart failure with reduced ejection fraction, Atrial fibrillation rate control.

Magnesium sulfate reduces cardiac arrhythmias and electrolyte imbalance, while digoxin increases cardiac contractility and slows atrioventricular conduction.

Magnesium sulfate reduces cardiac arrhythmias and electrolyte imbalance, while digoxin increases cardiac contractility and slows atrioventricular conduction. Used for Acute arrhythmias with hypomagnesemia, Heart failure with reduced ejection fraction, Atrial fibrillation rate control.

At a glance

Generic nameMagnesium sulfate and then Digoxin
SponsorSunnybrook Health Sciences Centre
Drug classElectrolyte supplement and cardiac glycoside combination
TargetNa+/K+-ATPase (digoxin); magnesium-dependent ion channels and enzymes (magnesium sulfate)
ModalitySmall molecule
Therapeutic areaCardiovascular
PhasePhase 3

Mechanism of action

Magnesium sulfate acts as an electrolyte replacement and antiarrhythmic agent, stabilizing cardiac membrane potential and reducing ectopic activity. Digoxin is a cardiac glycoside that inhibits the Na+/K+-ATPase pump, increasing intracellular calcium and enhancing myocardial contractility while also slowing conduction through the AV node via vagomimetic effects. Together, they may be used sequentially to manage acute arrhythmias and heart failure.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Magnesium sulfate and then Digoxin

What is Magnesium sulfate and then Digoxin?

Magnesium sulfate and then Digoxin is a Electrolyte supplement and cardiac glycoside combination drug developed by Sunnybrook Health Sciences Centre, indicated for Acute arrhythmias with hypomagnesemia, Heart failure with reduced ejection fraction, Atrial fibrillation rate control.

How does Magnesium sulfate and then Digoxin work?

Magnesium sulfate reduces cardiac arrhythmias and electrolyte imbalance, while digoxin increases cardiac contractility and slows atrioventricular conduction.

What is Magnesium sulfate and then Digoxin used for?

Magnesium sulfate and then Digoxin is indicated for Acute arrhythmias with hypomagnesemia, Heart failure with reduced ejection fraction, Atrial fibrillation rate control.

Who makes Magnesium sulfate and then Digoxin?

Magnesium sulfate and then Digoxin is developed by Sunnybrook Health Sciences Centre (see full Sunnybrook Health Sciences Centre pipeline at /company/sunnybrook-health-sciences-centre).

What drug class is Magnesium sulfate and then Digoxin in?

Magnesium sulfate and then Digoxin belongs to the Electrolyte supplement and cardiac glycoside combination class. See all Electrolyte supplement and cardiac glycoside combination drugs at /class/electrolyte-supplement-and-cardiac-glycoside-combination.

What development phase is Magnesium sulfate and then Digoxin in?

Magnesium sulfate and then Digoxin is in Phase 3.

What are the side effects of Magnesium sulfate and then Digoxin?

Common side effects of Magnesium sulfate and then Digoxin include Hypermagnesemia (with magnesium sulfate), Digoxin toxicity (nausea, arrhythmias, visual disturbances), Hypokalemia exacerbation, Bradycardia, AV block.

What does Magnesium sulfate and then Digoxin target?

Magnesium sulfate and then Digoxin targets Na+/K+-ATPase (digoxin); magnesium-dependent ion channels and enzymes (magnesium sulfate) and is a Electrolyte supplement and cardiac glycoside combination.

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