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NCT05287191: MAGNAM
MAGNAM Trial, Magnesium Versus Amiodarone in Atrial Fibrillation in Critical Care
Phase 3 trial testing Magnesium sulfate and then Digoxin in Atrial Fibrillation New Onset in 200 participants. Currently enrolling.
31 October 2025
Quick facts
| Lead sponsor | Sunnybrook Health Sciences Centre |
|---|---|
| Phase | Phase 3 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 200 |
| Start date | 5 January 2022 |
| Primary completion | 31 October 2025 |
| Estimated completion | 30 April 2026 |
| Sites | 5 locations across Canada |
Drugs / interventions tested
- Magnesium sulfate and then Digoxin — full drug profile →
- Amiodarone (AMIODARONE) — full drug profile →
Conditions studied
- Atrial Fibrillation New Onset — all drugs for Atrial Fibrillation New Onset →
Sponsor
Sunnybrook Health Sciences Centre — full company profile →
Who can join
18 and older, any sex, with Atrial Fibrillation New Onset. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A multi-centre, non-blinded, comparative effectiveness, randomised controlled trial. Patients will be prospectively enrolled from Critical Care Units and will be assessed for study enrollment based on inclusion/exclusion criteria at the time of the onset of fast atrial fibrillation (AF)(irregular and often rapid heart rate). The authors hypothesize that high dose Magnesium Sulphate with the addition of Digoxin as a second line treatment will improve the success rate in returning the heart to normal rhythm as well as speed of resolution of critical illness in new onset rapid atrial fibrillation in the critically ill cared for in general ICUs.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05287191
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Atrial Fibrillation New Onset
Currently open trials in the same condition.
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- NCT05444335 — Screening for Atrial Fibrillation in Elderly Women Older Than 70 Years · NA · active not recruiting
- NCT05229211 — Tracking Atrial Fibrillation After Intensive Care Admission · recruiting
Other Sunnybrook Health Sciences Centre trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05287191 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sunnybrook Health Sciences Centre
- Last refreshed: 25 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05287191.
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