M.D. Anderson Cancer Center

Quick facts

Marketed products

• 6-Thioguanine
• ABLC · Oncology
• Ara-C · Oncology
  Ara-C is a cytidine analog that inhibits DNA synthesis by being incorporated into DNA and blocking cell division, primarily affecting rapidly dividing cancer cells.
• Avandamet · Other
• Bioperine · Other
• Cladribine (CLAD) · Oncology
  Cladribine is a purine nucleoside analog that is phosphorylated intracellularly and incorporated into DNA, causing strand breaks and apoptosis in lymphoid cells.
• Dalteparin (Fragmin) · Cardiovascular
  Dalteparin is a low-molecular-weight heparin that inhibits blood coagulation by enhancing the activity of antithrombin III against factor Xa and thrombin.
• Edetate Calcium Disodium · Toxicology
  Edetate calcium disodium is a chelating agent that binds and removes heavy metals (particularly lead) from the body by forming stable complexes that are excreted in urine.
• Erwinase · Oncology
• Fentanyl Nasal Spray
• Filgrastim-sndz · Oncology
  Filgrastim-sndz is a granulocyte colony-stimulating factor (G-CSF) analog that stimulates the proliferation and differentiation of neutrophil progenitor cells in bone marrow.
• Gleevec · Oncology
• Hydromorphone PCA
• Ibritumomab Tiuxetan (Zevalin) · Oncology
  Ibritumomab tiuxetan is a radiolabeled monoclonal antibody that binds to CD20 on B cells and delivers yttrium-90 radiation directly to tumor cells.
• Methoxsalen+ECP · Oncology
  Methoxsalen combined with extracorporeal photochemotherapy (ECP) uses a photosensitizing agent activated by ultraviolet A light to induce apoptosis in circulating malignant T cells.
• Nesiritide (Natrecor) · Cardiovascular
  Nesiritide is a recombinant B-type natriuretic peptide that binds to natriuretic peptide receptors, promoting vasodilation and sodium excretion to reduce cardiac preload and afterload.
• PCV20 · Other
• Pegylated liposomal doxorubicin hydrochloride · Oncology
  Pegylated liposomal doxorubicin delivers the chemotherapy agent doxorubicin encapsulated in liposomes coated with polyethylene glycol, which intercalates into DNA and inhibits topoisomerase II while reducing cardiotoxicity through prolonged circulation and selective tumor accumulation.
• Pepcid · Other
• Proflavine Hemisulfate · Oncology
  Proflavine hemisulfate is an acridine dye that intercalates into DNA and generates reactive oxygen species, causing direct antimicrobial and antiproliferative effects.
• Qutenza Patch · Pain Management / Neurology
  Qutenza is a topical capsaicin patch that desensitizes nociceptors (pain-sensing nerve fibers) by depleting substance P, reducing localized neuropathic pain.
• Revlimid · Oncology
• Tarceva · Oncology
• Taxol · Oncology
• Tc99m sestamibi · Cardiology / Nuclear Medicine
  Tc-99m sestamibi is a radiotracer that accumulates in mitochondria of viable cells, allowing visualization of myocardial perfusion and detection of ischemia via nuclear imaging.
• Teriparatide (Forteo) · Endocrinology / Bone Metabolism
  Teriparatide is a recombinant parathyroid hormone analog that stimulates osteoblasts to increase bone formation and remodeling.
• Thymoglobulin (ATG) · Immunology / Hematology-Oncology
  Thymoglobulin is a polyclonal antithymocyte globulin that depletes T lymphocytes by binding to multiple T-cell antigens and triggering their destruction.
• Vitamin C (Ascorbic Acid) · Oncology
  Vitamin C acts as an antioxidant and cofactor for enzymatic reactions, and at high doses may generate reactive oxygen species to selectively target cancer cells.
• VUEWAY · Other

Phase 3 pipeline

• Actonel (Risedronate) · Bone metabolism / Rheumatology
  Risedronate inhibits bone resorption by binding to hydroxyapatite on bone surfaces and inhibiting osteoclast activity.
• Antiandrogen Therapy · Oncology
  Antiandrogen therapy blocks the effects of androgens (male hormones) by inhibiting androgen receptor signaling, thereby slowing or stopping the growth of androgen-dependent cancer cells.
• Bleomycin Sulfate (BLM) · Oncology
  Bleomycin is a chemotherapeutic antibiotic that binds to DNA and causes strand breaks, leading to cell death.
• Calaspargase pegol-mknl · Oncology
  Calaspargase pegol-mknl is a pegylated asparaginase that depletes asparagine, an amino acid required for leukemic cell survival and proliferation.
• Dacarbazine (DTIC) · Oncology
  Dacarbazine is an alkylating agent that cross-links DNA, preventing cell division and causing cancer cell death.
• Fentanyl Buccal Tablet · Oncology
  Fentanyl buccal tablet delivers the opioid fentanyl through the buccal mucosa to provide rapid analgesia by binding to mu opioid receptors in the central nervous system.
• Filgrastim SD/01 · Oncology
  Filgrastim is a granulocyte colony-stimulating factor (G-CSF) that stimulates the production and release of neutrophils from bone marrow to increase white blood cell counts.
• Fluorouracil/Calcipotriene · Oncology
  Fluorouracil inhibits thymidylate synthase to disrupt DNA synthesis, while calcipotriene promotes keratinocyte differentiation and immune modulation for topical anticancer effect.
• G-CSF (Filgrastim) · Oncology
  Filgrastim is a granulocyte colony-stimulating factor (G-CSF) that stimulates the bone marrow to produce and release neutrophils into the bloodstream.
• GSK2118436 · Oncology
  GSK2118436 is a BRAF V600E inhibitor that blocks mutant BRAF kinase signaling in melanoma cells.
• High Dose Melphalan · Oncology
  High-dose melphalan is an alkylating agent that crosslinks DNA strands, causing cell death, and is used in high doses followed by stem cell rescue to treat hematologic malignancies.
• I-131 Iodocholesterol · Oncology
  I-131 Iodocholesterol is a radiolabeled cholesterol analog that localizes to adrenocortical tissue and delivers targeted radiation for imaging and therapeutic purposes in adrenocortical carcinoma.
• I-131 Metaiodobenzylguanidine · Oncology
  I-131 MIBG is a radioactive iodine-labeled compound that selectively accumulates in neuroendocrine tumors and delivers targeted radiation therapy to kill cancer cells.
• Imatinib mesylate (STI571) · Oncology
  Imatinib is a tyrosine kinase inhibitor that blocks the BCR-ABL fusion protein and other kinases, preventing abnormal cell proliferation in chronic myeloid leukemia and other cancers.
• Lapine T-Lymphocyte Immune Globulin · Immunology, Hematology, Transplantation
  Lapine T-lymphocyte immune globulin depletes T lymphocytes to suppress immune rejection and graft-versus-host disease.
• Novantrone · Other
• Paclitaxel (Taxol) · Oncology
  Paclitaxel stabilizes microtubules by binding to β-tubulin, preventing their depolymerization and causing cell cycle arrest and apoptosis in cancer cells.
• Radiation Therapy · Oncology
  Radiation therapy uses high-energy ionizing radiation to damage cancer cell DNA and trigger cell death.
• Vitamin Supplements · Nutrition
  Vitamin supplements provide essential nutrients to support various bodily functions.

Phase 2 pipeline

• Cigarette · Other
• Lisaftoclax · Other
• Luprolide · Other
• Nadunolimab · Other
• P-Sam

Phase 1 pipeline

• Alpharadin · Oncology
• Anti-GITR Agonistic Monoclonal Antibody BMS-986156
• Carboplatin MTD
• Chemotherapy for hematologic malignancy
• Cytrabine · Other
• Hyperpolarized 13-C-pyruvate
• Listaftoclax · Other
• Rituximab for Patients with B-Cell Malignancies
• Thrombopoietin · Cardiovascular
• Zinecard · Cardiovascular

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• M.D. Anderson Cancer Center portfolio CI brief
• M.D. Anderson Cancer Center pipeline updates RSS

Frequently asked questions about M.D. Anderson Cancer Center

Related

• 6-Thioguanine
• ABLC · Oncology
• Ara-C · Oncology
• Avandamet · Other
• Bioperine · Other
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