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Thymoglobulin (ATG)
Thymoglobulin (ATG) is a Polyclonal antithymocyte globulin (ATG) Small molecule drug developed by M.D. Anderson Cancer Center. It is currently FDA-approved for Acute rejection in renal transplant recipients, Aplastic anemia (severe), Graft-versus-host disease (GVHD) prophylaxis in hematopoietic stem cell transplantation. Also known as: Thymoglobulin, Antithymocyte Globulin, Anti-thymocyte globulin, Antithymocyte globulin.
Thymoglobulin is a polyclonal antithymocyte globulin that depletes T lymphocytes by binding to multiple T-cell antigens and triggering their destruction.
Thymoglobulin (ATG) is a small molecule used to treat various blood-related conditions, including Aplastic Anemia, Immunosuppression, Thrombocytopenia, Pancytopenia, and Neutropenia. It is administered as part of conditioning regimens, often in combination with other medications such as Cyclophosphamide and Fludarabine, to prepare patients for unrelated donor transplantation.
At a glance
| Generic name | Thymoglobulin (ATG) |
|---|---|
| Also known as | Thymoglobulin, Antithymocyte Globulin, Anti-thymocyte globulin, Antithymocyte globulin, Thymoglobulin, Genzyme |
| Sponsor | M.D. Anderson Cancer Center |
| Drug class | Polyclonal antithymocyte globulin (ATG) |
| Target | Multiple T-cell antigens (CD2, CD3, CD4, CD8, CD11a, CD18, CD25, HLA-DR) |
| Modality | Small molecule |
| Therapeutic area | Immunology / Hematology-Oncology |
| Phase | FDA-approved |
Mechanism of action
Thymoglobulin is derived from immunizing rabbits with human thymus lymphocytes, producing antibodies against a broad range of T-cell surface antigens including CD2, CD3, CD4, CD8, CD11a, CD18, CD25, and HLA-DR. Upon administration, these antibodies bind to circulating and tissue-resident T cells, leading to complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and opsonization-mediated clearance. This results in profound T-cell depletion, suppressing the cellular immune response.
Approved indications
- Acute rejection in renal transplant recipients
- Aplastic anemia (severe)
- Graft-versus-host disease (GVHD) prophylaxis in hematopoietic stem cell transplantation
Common side effects
- Fever
- Chills
- Leukopenia
- Thrombocytopenia
- Infection
- Rash
- Serum sickness
- Cytokine release syndrome
Key clinical trials
- A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation (PHASE2, PHASE3)
- Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis (PHASE4)
- Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients (PHASE2)
- A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (PHASE1, PHASE2)
- Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders (PHASE2)
- Immune Tolerance Induction After Liver Transplantation (PHASE1, PHASE2)
- Allo HSCT for High Risk Hemoglobinopathies (PHASE2)
- Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Thiotepa in Treating Patients With Non-malignant Disorders (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Thymoglobulin (ATG) CI brief — competitive landscape report
- Thymoglobulin (ATG) updates RSS · CI watch RSS
- M.D. Anderson Cancer Center portfolio CI
Frequently asked questions about Thymoglobulin (ATG)
What is Thymoglobulin (ATG)?
How does Thymoglobulin (ATG) work?
What is Thymoglobulin (ATG) used for?
Who makes Thymoglobulin (ATG)?
Is Thymoglobulin (ATG) also known as anything else?
What drug class is Thymoglobulin (ATG) in?
What development phase is Thymoglobulin (ATG) in?
What are the side effects of Thymoglobulin (ATG)?
What does Thymoglobulin (ATG) target?
Related
- Drug class: All Polyclonal antithymocyte globulin (ATG) drugs
- Target: All drugs targeting Multiple T-cell antigens (CD2, CD3, CD4, CD8, CD11a, CD18, CD25, HLA-DR)
- Manufacturer: M.D. Anderson Cancer Center — full pipeline
- Therapeutic area: All drugs in Immunology / Hematology-Oncology
- Indication: Drugs for Acute rejection in renal transplant recipients
- Indication: Drugs for Aplastic anemia (severe)
- Indication: Drugs for Graft-versus-host disease (GVHD) prophylaxis in hematopoietic stem cell transplantation
- Also known as: Thymoglobulin, Antithymocyte Globulin, Anti-thymocyte globulin, Antithymocyte globulin, Thymoglobulin, Genzyme
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing