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Lapine T-Lymphocyte Immune Globulin
Lapine T-Lymphocyte Immune Globulin is a Antithymocyte globulin (ATG) Biologic drug developed by M.D. Anderson Cancer Center. It is currently in Phase 3 development for Prevention of acute rejection in organ transplantation, Treatment of severe aplastic anemia, Prevention and treatment of graft-versus-host disease. Also known as: Anti-Thymocyte Globulin Rabbit, Grafalon, Rabbit Anti-Human Thymocyte Globulin (RATG), Rabbit Anti-Thymocyte Globulin.
Lapine T-lymphocyte immune globulin depletes T lymphocytes to suppress immune rejection and graft-versus-host disease.
Lapine T-lymphocyte immune globulin depletes T lymphocytes to suppress immune rejection and graft-versus-host disease. Used for Prevention of acute rejection in organ transplantation, Treatment of severe aplastic anemia, Prevention and treatment of graft-versus-host disease.
At a glance
| Generic name | Lapine T-Lymphocyte Immune Globulin |
|---|---|
| Also known as | Anti-Thymocyte Globulin Rabbit, Grafalon, Rabbit Anti-Human Thymocyte Globulin (RATG), Rabbit Anti-Thymocyte Globulin, Rabbit Antithymocyte Globulin |
| Sponsor | M.D. Anderson Cancer Center |
| Drug class | Antithymocyte globulin (ATG) |
| Target | T lymphocyte surface antigens |
| Modality | Biologic |
| Therapeutic area | Immunology, Hematology, Transplantation |
| Phase | Phase 3 |
Mechanism of action
This is a polyclonal antithymocyte globulin (ATG) derived from rabbits immunized against human T lymphocytes. It binds to and eliminates circulating T cells, reducing the adaptive immune response. It is used in transplantation and severe aplastic anemia to prevent rejection and immune-mediated complications.
Approved indications
- Prevention of acute rejection in organ transplantation
- Treatment of severe aplastic anemia
- Prevention and treatment of graft-versus-host disease
Common side effects
- Fever
- Chills
- Leukopenia
- Thrombocytopenia
- Serum sickness
- Infection
Key clinical trials
- A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation (PHASE2, PHASE3)
- Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis (PHASE4)
- Uterine Transplantation and Pregnancy Induction in Women Affected by Absolute Uterine Infertility (NA)
- Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients (PHASE2)
- A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes (PHASE1, PHASE2)
- Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders (PHASE2)
- Immune Tolerance Induction After Liver Transplantation (PHASE1, PHASE2)
- Allo HSCT for High Risk Hemoglobinopathies (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lapine T-Lymphocyte Immune Globulin CI brief — competitive landscape report
- Lapine T-Lymphocyte Immune Globulin updates RSS · CI watch RSS
- M.D. Anderson Cancer Center portfolio CI
Frequently asked questions about Lapine T-Lymphocyte Immune Globulin
What is Lapine T-Lymphocyte Immune Globulin?
How does Lapine T-Lymphocyte Immune Globulin work?
What is Lapine T-Lymphocyte Immune Globulin used for?
Who makes Lapine T-Lymphocyte Immune Globulin?
Is Lapine T-Lymphocyte Immune Globulin also known as anything else?
What drug class is Lapine T-Lymphocyte Immune Globulin in?
What development phase is Lapine T-Lymphocyte Immune Globulin in?
What are the side effects of Lapine T-Lymphocyte Immune Globulin?
What does Lapine T-Lymphocyte Immune Globulin target?
Related
- Drug class: All Antithymocyte globulin (ATG) drugs
- Target: All drugs targeting T lymphocyte surface antigens
- Manufacturer: M.D. Anderson Cancer Center — full pipeline
- Therapeutic area: All drugs in Immunology, Hematology, Transplantation
- Indication: Drugs for Prevention of acute rejection in organ transplantation
- Indication: Drugs for Treatment of severe aplastic anemia
- Indication: Drugs for Prevention and treatment of graft-versus-host disease
- Also known as: Anti-Thymocyte Globulin Rabbit, Grafalon, Rabbit Anti-Human Thymocyte Globulin (RATG), Rabbit Anti-Thymocyte Globulin, Rabbit Antithymocyte Globulin
- Compare: Lapine T-Lymphocyte Immune Globulin vs similar drugs
- Pricing: Lapine T-Lymphocyte Immune Globulin cost, discount & access