Topical antibiotic combination

This page covers all Topical antibiotic combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Bacterial ribosome (clindamycin); reactive oxygen species generation (benzoyl peroxide), Bacterial isoleucyl-tRNA synthetase (mupirocin); bacterial cell membrane and proteins (chlorhexidine), Bacterial 50S ribosome (clindamycin); reactive oxygen species generation (benzoyl peroxide).

Targets

Bacterial ribosome (clindamycin); reactive oxygen species generation (benzoyl peroxide) · Bacterial isoleucyl-tRNA synthetase (mupirocin); bacterial cell membrane and proteins (chlorhexidine) · Bacterial 50S ribosome (clindamycin); reactive oxygen species generation (benzoyl peroxide) · Propionibacterium acnes (bacterial target); benzoyl peroxide acts via oxidative mechanism; clindamycin inhibits bacterial protein synthesis · Bacterial isoleucyl-tRNA synthetase (mupirocin); bacterial cell membrane (chlorhexidine) · Bacterial cell wall (bacitracin), bacterial ribosome (neomycin), bacterial cell membrane (polymyxin B) · Bacterial ribosomes (clindamycin); reactive oxygen species generation (benzoyl peroxide) · Bacterial ribosome (clindamycin); oxidative stress induction (benzoyl peroxide) · Bacterial cell wall (bacitracin) and bacterial cell membrane (polymyxin B) · Bacterial ribosome (clindamycin); oxidative mechanism (benzoyl peroxide)

Marketed (11)

• Acnatac® Gel right face · GWT-TUD GmbH · Dermatology
  Acnatac® Gel combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial and keratolytic agent) to reduce acne-causing bacteria and promote skin cell turnover.
• Intranasal Mupirocin and Topical Chlorhexidine · University of Maryland, Baltimore · Infectious Disease
  Intranasal mupirocin and topical chlorhexidine work together to eliminate and prevent nasal colonization of pathogenic bacteria, particularly Staphylococcus aureus.
• clindamycin 1% / benzoyl peroxide 5% tube · Sanofi · Dermatology
  Clindamycin kills acne-causing bacteria while benzoyl peroxide reduces sebum production and provides additional antimicrobial and keratolytic effects.
• Duac® fixed dose combination gel · GlaxoSmithKline · Dermatology
  Duac combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial oxidizing agent) to kill acne-causing bacteria and reduce inflammation.
• Duac Gel · Stiefel, a GSK Company · Dermatology
  Duac Gel combines benzoyl peroxide and clindamycin to kill acne-causing bacteria and reduce inflammation in acne lesions.
• Mupirocin + Chlorhexidin · B. Braun Medical SA · Dermatology / Infection Prevention
  Mupirocin inhibits bacterial protein synthesis while chlorhexidine disrupts bacterial cell membranes, providing broad-spectrum antimicrobial activity.
• Polysporin Triple · University Health Network, Toronto · Dermatology / Infection
  Polysporin Triple is a topical antibiotic combination that kills bacteria by inhibiting protein synthesis and cell wall integrity through multiple mechanisms.
• Benzoyl peroxide with clindamycin · Stiefel, a GSK Company · Dermatology
  Benzoyl peroxide kills acne-causing bacteria and reduces sebum production, while clindamycin is an antibiotic that inhibits bacterial protein synthesis.
• Acnatac® Gel left face · GWT-TUD GmbH · Dermatology
  Acnatac® Gel combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial oxidizing agent) to reduce acne-causing bacteria and inflammation on the skin.
• BENZOYL PEROXIDE/ CLINDAMYCIN · Stiefel, a GSK Company · Dermatology
  Benzoyl peroxide kills acne-causing bacteria and reduces sebum production, while clindamycin is an antibiotic that inhibits bacterial protein synthesis.
• Polysporin Ointment · University of British Columbia · Dermatology / Infectious Disease
  Polysporin Ointment combines two antibiotics (bacitracin and polymyxin B) that work synergistically to inhibit bacterial cell wall synthesis and disrupt cell membrane integrity.

Phase 3 pipeline (5)

• Onexton™ Gel · Sun Pharmaceutical Industries, Inc. · Dermatology
  Onexton is a topical combination gel containing clindamycin and benzoyl peroxide that reduces acne by killing bacteria and decreasing sebum production.
• Duac™Once Daily Gel · GlaxoSmithKline · Dermatology
  Duac combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial oxidizing agent) to reduce acne-causing bacteria and decrease inflammation in acne lesions.
• GSK2585823(CLDM 1%-BPO 3% gel) · GlaxoSmithKline · Dermatology
  This combination gel delivers clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial and keratolytic agent) topically to reduce acne-causing bacteria and inflammation.
• Acanya Gel · Padagis LLC · Dermatology
  Acanya Gel combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial oxidizing agent) to reduce acne-causing bacteria and decrease sebum production.
• Clindamycin Phosphate / Benzoyl Peroxide Gel · Watson Laboratories, Inc. · Dermatology
  Clindamycin reduces acne-causing bacteria while benzoyl peroxide provides antimicrobial and keratolytic effects to treat acne vulgaris.