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Duac™Once Daily Gel
Duac combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial oxidizing agent) to reduce acne-causing bacteria and decrease inflammation in acne lesions.
Duac combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial oxidizing agent) to reduce acne-causing bacteria and decrease inflammation in acne lesions. Used for Acne vulgaris.
At a glance
| Generic name | Duac™Once Daily Gel |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Topical antibiotic combination |
| Target | Bacterial 50S ribosome (clindamycin); non-specific oxidative antimicrobial (benzoyl peroxide) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, effectively killing Propionibacterium acnes. Benzoyl peroxide generates reactive oxygen species that have broad antimicrobial activity and also help reduce sebum production and comedone formation. The combination provides synergistic antibacterial and anti-inflammatory effects.
Approved indications
- Acne vulgaris
Common side effects
- Skin irritation/erythema
- Dryness
- Peeling
- Burning/stinging
Key clinical trials
- A Study Comparing Clindamycin and Benzoyl Peroxide Gel 1.2%/3.75% to Onexton™ Gel in the Treatment of Acne Vulgaris (PHASE1)
- Compare the Tolerance of Clindamycin 1% /Benzoyl Peroxide (BPO) 5% Gel to Clindamycin 1.2%/ BPO 2.5% Topical Medications (PHASE4)
- A Efficacy and Safety of Duac™Compared With Clindamycin Phosphate Gel in the Treatment of Mild to Moderate Acne Vulgaris (PHASE3)
- A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Duac™Once Daily Gel CI brief — competitive landscape report
- Duac™Once Daily Gel updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI