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BENZOYL PEROXIDE/ CLINDAMYCIN
Benzoyl peroxide kills acne-causing bacteria and reduces sebum production, while clindamycin is an antibiotic that inhibits bacterial protein synthesis.
Benzoyl peroxide kills acne-causing bacteria and reduces sebum production, while clindamycin is an antibiotic that inhibits bacterial protein synthesis. Used for Acne vulgaris.
At a glance
| Generic name | BENZOYL PEROXIDE/ CLINDAMYCIN |
|---|---|
| Sponsor | Stiefel, a GSK Company |
| Drug class | Topical antibiotic combination |
| Target | Bacterial ribosome (clindamycin); reactive oxygen species generation (benzoyl peroxide) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Benzoyl peroxide is a topical oxidizing agent that generates reactive oxygen species to kill Cutibacterium acnes (formerly Propionibacterium acnes) and has keratolytic properties. Clindamycin is a lincosamide antibiotic that binds to bacterial ribosomes and inhibits protein synthesis. Together, they provide synergistic antibacterial activity and reduce inflammation in acne lesions.
Approved indications
- Acne vulgaris
Common side effects
- Skin irritation
- Dryness
- Erythema
- Peeling
- Contact dermatitis
Key clinical trials
- Evaluation of Topical Dutasteride as a Potential New Therapy for Facial Acne Vulgaris Versus the Triple Combination Therapy (Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel) (NA)
- Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Triple Combination Gel in Canadian Patients With Acne Vulgaris
- Experience With Topical Acne Treatment (EARLY_PHASE1)
- A Study Assessing the Efficacy and Safety of Combined Use of Clascoterone 1% Cream and Duac Gel (Benzoyl Peroxide/Clindamycin) for the Treatment of Acne (PHASE4)
- The Relationship Between Microbioma Balance and Acne Vulgaris as a New Acne Treatment (PHASE2)
- A Study Comparing Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Topical Gel 0.15%;3.1%;1.2% (Taro Pharmaceuticals U.S.A., Inc.) and CABTREO Topical Gel for the Treatment of Acne Vulgaris. (PHASE1)
- Clinical Study Between Two 1% Clindamycin/5% Benzoyl Peroxide Topical Gel Formulations (NA)
- Cutibacterium Dermal Colonization: Implications for Total Hip Arthroplasty (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- BENZOYL PEROXIDE/ CLINDAMYCIN CI brief — competitive landscape report
- BENZOYL PEROXIDE/ CLINDAMYCIN updates RSS · CI watch RSS
- Stiefel, a GSK Company portfolio CI