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Clindamycin Phosphate / Benzoyl Peroxide Gel
Clindamycin reduces acne-causing bacteria while benzoyl peroxide provides antimicrobial and keratolytic effects to treat acne vulgaris.
Clindamycin reduces acne-causing bacteria while benzoyl peroxide provides antimicrobial and keratolytic effects to treat acne vulgaris. Used for Acne vulgaris.
At a glance
| Generic name | Clindamycin Phosphate / Benzoyl Peroxide Gel |
|---|---|
| Also known as | Generic |
| Sponsor | Watson Laboratories, Inc. |
| Drug class | Topical antibiotic combination |
| Target | Bacterial ribosome (clindamycin); oxidative antimicrobial mechanism (benzoyl peroxide) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Clindamycin phosphate is a lincosamide antibiotic that inhibits bacterial protein synthesis, reducing Cutibacterium acnes (formerly Propionibacterium acnes) colonization. Benzoyl peroxide acts as an oxidizing agent with broad antimicrobial activity and helps normalize keratinization. The combination provides synergistic antibacterial effects while reducing the risk of antibiotic resistance.
Approved indications
- Acne vulgaris
Common side effects
- Skin irritation/erythema
- Dryness
- Peeling
- Burning/stinging
Key clinical trials
- Evaluation of Topical Dutasteride as a Potential New Therapy for Facial Acne Vulgaris Versus the Triple Combination Therapy (Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel) (NA)
- Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Triple Combination Gel in Canadian Patients With Acne Vulgaris
- Experience With Topical Acne Treatment (EARLY_PHASE1)
- A Study Assessing the Efficacy and Safety of Combined Use of Clascoterone 1% Cream and Duac Gel (Benzoyl Peroxide/Clindamycin) for the Treatment of Acne (PHASE4)
- A Study Comparing Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Topical Gel 0.15%;3.1%;1.2% (Taro Pharmaceuticals U.S.A., Inc.) and CABTREO Topical Gel for the Treatment of Acne Vulgaris. (PHASE1)
- Clinical Study Between Two 1% Clindamycin/5% Benzoyl Peroxide Topical Gel Formulations (NA)
- Cutibacterium Dermal Colonization: Implications for Total Hip Arthroplasty (PHASE4)
- Combination Therapy With Differin® Gel 0.3% and Duac® (Clindamycin/Benzoyl Peroxide Gel) in Subjects With Acne Vulgaris (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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