What are Thiazide Diuretic drugs?

Thiazide Diuretic drugs are pharmacologic agents that share a common mechanism (typically targeting Solute carrier family 12 member 3). 11 are currently marketed, with 1 more in clinical development.

What are the marketed Thiazide Diuretic drugs?

Marketed Thiazide Diuretic drugs include Corzide, Saluron, thiazide diuretics, Thiazide Treatment Group, Hydrochlorothiazide (HCT), Hydrochlorothiazide (HCTZ).

Thiazide Diuretic

11 marketed 1 in Phase 3

This page covers all Thiazide Diuretic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Solute carrier family 12 member 3, Sodium-chloride cotransporter (NCC).

Targets

Solute carrier family 12 member 3 · Sodium-chloride cotransporter (NCC)

Marketed (11)

Corzide · Cardiovascular
Saluron · Shire Llc · Immunology
thiazide diuretics · Seiji Umemoto, M.D., Ph.D. · Cardiovascular
Thiazide diuretics inhibit sodium and chloride reabsorption in the distal convoluted tubule of the nephron, increasing urine output and reducing blood volume and blood pressure.
Thiazide Treatment Group · Cedars-Sinai Medical Center · Cardiovascular
Thiazide diuretics reduce blood pressure by decreasing sodium reabsorption in the distal convoluted tubule of the kidney, leading to increased sodium and water excretion and reduced blood volume.
Hydrochlorothiazide (HCT) · Takeda · Cardiovascular
Hydrochlorothiazide inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, promoting water and electrolyte excretion to reduce blood volume and blood pressure.
Hydrochlorothiazide (HCTZ) · Novartis · Cardiovascular
Hydrochlorothiazide inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, promoting water and electrolyte excretion to reduce blood volume and blood pressure.
Chlorothiazide Injection · University of Virginia · Cardiovascular
Chlorothiazide inhibits sodium chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of sodium, chloride, and water.
Enduron · Cardiovascular
Intensified Thiazide Treatment Group · Cedars-Sinai Medical Center · Cardiovascular
Intensified thiazide treatment lowers blood pressure by increasing urinary sodium and water excretion through inhibition of sodium-chloride cotransport in the distal convoluted tubule.
Thiazide or Thiazide-like diuretics · National University of Ireland, Galway, Ireland · Cardiovascular
Thiazide and thiazide-like diuretics inhibit sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary sodium and water excretion to reduce blood volume and blood pressure.
Diuril · Salix Pharms · Metabolic

Phase 3 pipeline (1)

HCTZ monotherapy · Bristol-Myers Squibb · Cardiovascular
HCTZ (hydrochlorothiazide) is a thiazide diuretic that reduces blood pressure by inhibiting sodium and chloride reabsorption in the distal convoluted tubule of the kidney.