Last reviewed 2026-06-02 · How we verify

Enduron (methylclothiazide)

FDA-approved active Under review Quality 10/100

Enduron (generic name: methylclothiazide) is a Thiazide Diuretic drug. It is currently FDA-approved (first approved 1960) for Edema, Hypertensive disorder, Peripheral Edema due to Chronic Heart Failure.

Enduron is a small molecule that inhibits the thiazide-sensitive sodium-chloride cotransporter, and it has been studied in clinical trials for various conditions including osteoarthritis, post-traumatic arthritis, and avascular necrosis.

At a glance

Generic name	methylclothiazide
Drug class	Thiazide Diuretic
Target	Solute carrier family 12 member 3
Therapeutic area	Cardiovascular
Phase	FDA-approved
First approval	1960

Approved indications

Edema
Hypertensive disorder
Peripheral Edema due to Chronic Heart Failure
Pulmonary Edema due to Chronic Heart Failure
Renal Disease with Edema

Common side effects

No common side effects on file.

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
FDA label	Mechanism, indications, dosing, boxed warnings, drug interactions

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

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Frequently asked questions about Enduron

What is Enduron?

Enduron (methylclothiazide) is a Thiazide Diuretic drug, indicated for Edema, Hypertensive disorder, Peripheral Edema due to Chronic Heart Failure.

What is Enduron used for?

Enduron is indicated for Edema, Hypertensive disorder, Peripheral Edema due to Chronic Heart Failure, Pulmonary Edema due to Chronic Heart Failure, Renal Disease with Edema.

What is the generic name of Enduron?

methylclothiazide is the generic (nonproprietary) name of Enduron.

What drug class is Enduron in?

Enduron belongs to the Thiazide Diuretic class. See all Thiazide Diuretic drugs at /class/thiazide-diuretic.

When was Enduron approved?

Enduron was first approved on 1960.

What development phase is Enduron in?

Enduron is FDA-approved (marketed).

What does Enduron target?

Enduron targets Solute carrier family 12 member 3 and is a Thiazide Diuretic.

Drug class: All Thiazide Diuretic drugs
Target: All drugs targeting Solute carrier family 12 member 3
Manufacturer: — full pipeline
Therapeutic area: All drugs in Cardiovascular
Indication: Drugs for Edema
Indication: Drugs for Hypertensive disorder
Indication: Drugs for Peripheral Edema due to Chronic Heart Failure

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing