Last reviewed · How we verify
Diuril (CHLOROTHIAZIDE)
At a glance
| Generic name | CHLOROTHIAZIDE |
|---|---|
| Sponsor | Salix Pharms |
| Drug class | Thiazide Diuretic |
| Target | Solute carrier family 12 member 3 |
| Modality | Small molecule |
| Therapeutic area | Metabolic |
| Phase | FDA-approved |
| First approval | 1958 |
Approved indications
- Edema in Congestive Heart Failure
- Edema in Hepatic Cirrhosis
- Edema in Corticosteroid Therapy
- Edema in Estrogen Therapy
- Edema in Nephrotic Syndrome
- Edema in Acute Glomerulonephritis
- Edema in Chronic Renal Failure
- Pathologic Edema in Pregnancy
- Severe Discomforting Edema in Pregnancy
Common side effects
- Pancreatitis
- Hypotension
- Leukopenia
- Thrombocytopenia
- Aplastic anemia
- Agranulocytosis
- Hemolytic anemia
- Necrotizing angiitis
- Pneumonitis
- Pulmonary edema
- Electrolyte imbalance
- Hyperglycemia
Drug interactions
- cisapride
- dofetilide
- lithium
Key clinical trials
- POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure (PHASE2,PHASE3)
- Triple Antihypertensive Medication After Intracerebral Hemorrhage for Blood Pressure Control (NA)
- HYDROchlorothiazide to PROTECT Polycystic Kidney Disease Patients and Improve Their Quality of Life (PHASE3)
- Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension (PHASE4)
- Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
- Protocol of Diuretics Use in Congestive Therapy in Heart Failure (PHASE4)
- Pharmacokinetics of Drugs Administered to Children
- Diuretics and Volume Overload in Early CKD (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |