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thiazide diuretics
Thiazide diuretics inhibit sodium and chloride reabsorption in the distal convoluted tubule of the nephron, increasing urine output and reducing blood volume and blood pressure.
Thiazide diuretics inhibit sodium and chloride reabsorption in the distal convoluted tubule of the nephron, increasing urine output and reducing blood volume and blood pressure. Used for Hypertension, Edema associated with congestive heart failure, Edema associated with hepatic cirrhosis.
At a glance
| Generic name | thiazide diuretics |
|---|---|
| Also known as | benidipie, thiazide diuretics |
| Sponsor | Seiji Umemoto, M.D., Ph.D. |
| Drug class | Thiazide diuretic |
| Target | Sodium-chloride cotransporter (NCC) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Thiazides block the sodium-chloride cotransporter (NCC) in the distal convoluted tubule, preventing electrolyte reabsorption and promoting osmotic diuresis. This reduces intravascular volume and total body sodium, leading to decreased blood pressure. Over time, they also cause mild vasodilation through unknown mechanisms, contributing to sustained antihypertensive effects.
Approved indications
- Hypertension
- Edema associated with congestive heart failure
- Edema associated with hepatic cirrhosis
- Edema associated with renal disease
Common side effects
- Hypokalemia
- Hyperglycemia
- Hyperuricemia
- Hyponatremia
- Hypotension
- Ototoxicity (high doses)
- Photosensitivity
Key clinical trials
- Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES) (NA)
- POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure (PHASE2, PHASE3)
- Baroreflex Activation Therapy for Heart Failure (NA)
- Focusing on the Menopausal Transition to Improve Mid-Life Women's Health (PHASE2, PHASE3)
- Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics (NA)
- Protocol of Diuretics Use in Congestive Therapy in Heart Failure (PHASE4)
- A Study of Blood Pressure Control During Cancer Treatment (PHASE2)
- Diuretics and Volume Overload in Early CKD (PHASE4)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |