Nucleoside analog

This page covers all Nucleoside analog drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting RNA-dependent RNA polymerase, DNA, viral DNA polymerase.

Targets

RNA-dependent RNA polymerase · DNA · viral DNA polymerase · Ribonucleotide reductase · Thymidine kinase 1 · RNA polymerase · Ribonucleotide reductase, DNA polymerase alpha · DNA polymerase · viral RNA-dependent RNA polymerase · Thymidylate synthase

Marketed (3)

• Nucleoside Analog (Substance) · Third Affiliated Hospital, Sun Yat-Sen University
  Nucleoside analogs inhibit viral or cancer cell replication by mimicking natural nucleosides and disrupting DNA/RNA synthesis.
• Current Regimen · University of Chicago · Infectious Diseases
  Repurposed to treat COVID-19 by inhibiting viral replication.
• Nucleoside Analogs · Third Affiliated Hospital, Sun Yat-Sen University · Virology / Oncology
  Nucleoside analogs are synthetic molecules that mimic natural nucleosides and inhibit viral or cancer cell replication by interfering with nucleic acid synthesis.

Phase 3 pipeline (8)

• Remdesivir-HU · University of Pecs · Infectious Diseases
  Remdesivir-HU is an antiviral medication that works by inhibiting viral RNA-dependent RNA polymerase.
• clofarabine (IV formulation) · Genzyme, a Sanofi Company · Oncology
  Clofarabine is a nucleoside analog that interferes with DNA synthesis, leading to cell death in rapidly dividing cancer cells.
• NOV03 · Bausch & Lomb Incorporated · Infectious Diseases
  NOV03 is an investigational antiviral medication.
• AG-920 · American Genomics, LLC · Oncology
  AG-920 is a prodrug of 2-fluoroadenine that is converted into its active form, which is a nucleoside analog.
• Trifluridine-tipiracil · The Methodist Hospital Research Institute · Oncology
  Trifluridine-tipiracil is a thymidine kinase 1 inhibitor that also has a thymidylate synthase inhibitor component, which works by interfering with DNA synthesis in cancer cells.
• RBV(48 weeks) · Tanabe Pharma Corporation · Infectious Diseases
  Ribavirin is an antiviral medication that works by inhibiting viral RNA synthesis.
• ribavirin with adaptation dose · Hospices Civils de Lyon · Infectious Diseases
  Ribavirin is an antiviral medication that works by inhibiting viral RNA synthesis.
• acyclovir in ME-609 vehicle · Medivir · Infectious Diseases
  Acyclovir is an antiviral medication that inhibits viral DNA synthesis by inhibiting viral DNA polymerase.

Phase 2 pipeline (7)

• Drug: gemcitabine, S-1 · Osaka Medical Center for Cancer and Cardiovascular Diseases · Oncology
  Inhibits DNA synthesis by inhibiting ribonucleotide reductase and DNA polymerase alpha
• IBI343,Gemcitabine, Albumin-bound Paclitaxel · Innovent Biologics (Suzhou) Co. Ltd. · Oncology
  Gemcitabine is a nucleoside analog that inhibits DNA synthesis by interfering with DNA polymerase.
• Fludarabine , cytarabine · Cooperative Study Group A for Hematology · Oncology
  Fludarabine is a nucleoside analog that inhibits DNA synthesis by interfering with ribonucleotide reductase.
• Gemcitabine, Cisplatin, Sunitinib · US Oncology Research · Oncology
  Gemcitabine is a nucleoside analog that inhibits DNA synthesis by inhibiting ribonucleotide reductase.
• Gemcitabine - 21 day cycle · Actuate Therapeutics Inc. · Oncology
  Inhibits DNA synthesis by inhibiting ribonucleotide reductase and DNA polymerase alpha
• HYML-122; cytarabine · Tarapeutics Science Inc. · Oncology
  inhibits DNA polymerase
• Gemcitabine - 28 day cycle · Actuate Therapeutics Inc. · Oncology
  Inhibits DNA synthesis by inhibiting ribonucleotide reductase and DNA polymerase alpha

Phase 1 pipeline (2)

• AT-527 single dose · Atea Pharmaceuticals, Inc. · Infectious Disease
  AT-527 is a nucleoside analog that inhibits viral RNA-dependent RNA polymerase, thereby blocking viral replication.
• 5-fluoro-2-deoxycytidine · City of Hope Medical Center · Oncology
  Inhibits thymidylate synthase