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acyclovir in ME-609 vehicle

Acyclovir is an antiviral medication that inhibits viral DNA synthesis by inhibiting viral DNA polymerase.

Acyclovir is an antiviral medication that inhibits viral DNA synthesis by inhibiting viral DNA polymerase. Used for Herpes simplex virus infections, Varicella-zoster virus infections, Herpes zoster.

At a glance

Mechanism of action

Acyclovir works by selectively inhibiting viral DNA polymerase, which is essential for viral replication. This results in the inhibition of viral DNA synthesis and ultimately, the reduction of viral replication. Acyclovir is a nucleoside analog that is selectively phosphorylated by viral thymidine kinase, which then acts as a prodrug to inhibit viral DNA polymerase.

Approved indications

• Herpes simplex virus infections
• Varicella-zoster virus infections
• Herpes zoster

Common side effects

• Nausea
• Headache
• Vomiting
• Diarrhea
• Abdominal pain

Key clinical trials

• Efficacy and Safety Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis (PHASE3)
• Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis in Immunocompromised Patients (PHASE3)
• Efficacy of Acyclovir in Combination With a Glucocorticosteroid on UV-Induced Herpes Labialis (PHASE2)

Primary sources

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Competitive intelligence

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