Last reviewed · How we verify
5-fluoro-2-deoxycytidine
Inhibits thymidylate synthase
Inhibits thymidylate synthase Used for Colorectal cancer.
At a glance
| Generic name | 5-fluoro-2-deoxycytidine |
|---|---|
| Also known as | FdCyd |
| Sponsor | City of Hope Medical Center |
| Drug class | Nucleoside analog |
| Target | Thymidylate synthase |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 1 |
Mechanism of action
5-fluoro-2-deoxycytidine is a thymidylate synthase inhibitor that works by interfering with DNA synthesis, leading to cell death in rapidly dividing cancer cells.
Approved indications
- Colorectal cancer
Common side effects
- Neutropenia
- Thrombocytopenia
- Fatigue
Key clinical trials
- Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer (PHASE2)
- Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study (PHASE2)
- FdCyd and THU for Advanced Solid Tumors (PHASE1)
- Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer (PHASE1)
- CAPEcitabine eXtension of Adjuvant Therapy for Pancreatic Adenocarcinoma: (CAPE-X) (PHASE2)
- Imaging Study for FdCyd and THU Cancer Treatment (EARLY_PHASE1)
- A Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine (FdCyd + THU) (PHASE2)
- A Study of LY2090314 and Chemotherapy in Participants With Metastatic Pancreatic Cancer (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- 5-fluoro-2-deoxycytidine CI brief — competitive landscape report
- 5-fluoro-2-deoxycytidine updates RSS · CI watch RSS
- City of Hope Medical Center portfolio CI