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Phase I/II Study of LY2090314 and Chemotherapy in Metastatic Pancreatic Cancer Patients With Metastases Amenable to Biopsy
Purpose of this phase I/II study is to test how well LY2090314 works in combination with different chemotherapies in treating participants with metastatic pancreatic cancer.
Details
| Lead sponsor | Eli Lilly and Company |
|---|---|
| Phase | Phase 1/Phase 2 |
| Status | TERMINATED |
| Enrolment | 13 |
| Start date | 2013-03 |
| Completion | 2015-06 |
Conditions
- Pancreatic Cancer
Interventions
- LY2090314
- FOLFOX
- Gemcitabine
- Nab-paclitaxel
Primary outcomes
- Change From Baseline to 4 Hours Post-Treatment on Day 0 in Glycogen Synthase Phosphorylation — Baseline, 4 Hours Post-Treatment on Day 0
Change in the phosphorylation level of glycogen synthase, a glycogen synthase kinase-3 beta (GSK-3beta) inhibitor, from baseline to 4 hours post-treatment on day 0 using tumor tissue and blood specimens.
Countries
United States