Anticonvulsant; mood stabilizer; histone deacetylase inhibitor
This page covers all Anticonvulsant; mood stabilizer; histone deacetylase inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting GABA synthesis/metabolism; histone deacetylase, Histone deacetylase 1, Histone deacetylase 6.
Targets
GABA synthesis/metabolism; histone deacetylase · Histone deacetylase 1 · Histone deacetylase 6 · Histone deacetylase (HDAC); GABA metabolism · HDACs · Histone deacetylase · Histone deacetylase 4 · Histone deacetylase; GABA metabolism; sodium and calcium channels · Histone deacetylases, DNA methyltransferases · Histone deacetylases
Marketed (11)
- Depakote DR · Massachusetts General Hospital · Neurology; Psychiatry
Depakote DR (divalproex sodium delayed-release) increases brain GABA levels and inhibits histone deacetylase, stabilizing neuronal membranes and reducing abnormal electrical activity. - Beleodaq · Acrotech Biopharma · Oncology
Beleodaq works by blocking the enzyme that removes acetyl groups from histones, altering gene expression. - Zolinza · Merck & Co. · Oncology
Zolinza works by blocking the action of histone deacetylase 6, an enzyme that removes acetyl groups from histones, leading to changes in gene expression. - Valproic acid, sodium salt · Sanofi · Neurology; Psychiatry; Oncology
Valproic acid inhibits histone deacetylases and enhances GABA neurotransmission, leading to increased inhibitory signaling in the central nervous system. - Sodium Valproate treatment · University of Pittsburgh · Neurology; Oncology
Sodium valproate inhibits histone deacetylase (HDAC) and enhances gamma-aminobutyric acid (GABA) neurotransmission in the central nervous system. - Istodax · Teva Pharms Usa Inc · Oncology
Romidepsin inhibits HDACs, leading to increased acetylation of histones and non-histone proteins, causing cell cycle arrest and apoptosis in cancer cells. - HG-group · Medical University of Vienna · Oncology
HG-group is a histone deacetylase inhibitor. - Duvyzat · Italfarmaco Spa · Rare Disease
Duvyzat works by blocking enzymes that compact chromatin and silence genes. - Farydak · Secura · Oncology
- BELINOSTAT
- Divalproex (DV) · Weill Medical College of Cornell University · Neurology; Psychiatry
Divalproex inhibits histone deacetylase and enhances GABA neurotransmission, leading to increased inhibitory signaling in the central nervous system.
Phase 3 pipeline (11)
- Tucidinostat, Azacitidine combined with CHOP · Peking Union Medical College Hospital · Oncology
Tucidinostat is a histone deacetylase inhibitor, while Azacitidine is a hypomethylating agent, and CHOP is a chemotherapy regimen. - XNW5004 placebo; Chidamide · Evopoint Biosciences Inc. · Oncology
Chidamide is a histone deacetylase inhibitor that works by blocking the activity of histone deacetylases, leading to the accumulation of acetylated histones and the activation of tumor suppressor genes. - Hydralazine and magnesium valproate · National Institute of Cancerología · Oncology
This combination uses hydralazine as a vasodilator and magnesium valproate as a histone deacetylase inhibitor to modulate vascular function and epigenetic pathways in cancer treatment. - Temozolomide + Valproic Acid · University of Göttingen · Oncology
Temozolomide is an alkylating agent that works by interfering with DNA replication, while Valproic Acid is a histone deacetylase inhibitor that modulates gene expression. - placebo to vorinostat · Merck Sharp & Dohme LLC · Oncology
Vorinostat is a histone deacetylase inhibitor that works by blocking the action of histone deacetylases, leading to the accumulation of acetylated histones and altered gene expression. - SHR2554 analog tablets; Chidamide · Jiangsu HengRui Medicine Co., Ltd. · Oncology
Chidamide is a histone deacetylase inhibitor that works by blocking the activity of histone deacetylases, leading to the accumulation of acetylated histones and the activation of tumor suppressor genes. - VEN combined with azacitidine · Nanfang Hospital, Southern Medical University · Oncology
VEN combined with azacitidine works by inhibiting DNA methyltransferase and histone deacetylase, leading to epigenetic modifications that promote cell differentiation and apoptosis in cancer cells. - TCbHP VS ddEC-THP · Tianjin Medical University Cancer Institute and Hospital · Oncology
TCbHP is a histone deacetylase inhibitor, which works by blocking the activity of histone deacetylases to modify gene expression. - TLK286 in Combination with Carboplatin · Telik · Oncology
TLK286 is a histone deacetylase inhibitor that works by blocking the activity of histone deacetylases, leading to the inhibition of cancer cell growth and induction of apoptosis. - Divalproex Sodium (Depakote) · National Institute on Drug Abuse (NIDA) · Neurology; Psychiatry
Divalproex sodium inhibits histone deacetylase and enhances GABA neurotransmission, stabilizing neuronal membranes and reducing abnormal electrical activity in the brain. - Purinostat Mesylate for Injection · Chengdu Zenitar Biomedical Technology Co., Ltd · Oncology
Purinostat Mesylate for Injection is a histone deacetylase inhibitor that works by blocking the activity of histone deacetylases, leading to the accumulation of acetylated histones and changes in gene expression.
Phase 2 pipeline (4)
- Aplidin® · PharmaMar · Oncology
Aplidin is a chemotherapeutic agent that works by inhibiting the enzyme histone deacetylase (HDAC). - CC-2001 · Celgene · Oncology
CC-2001 is a histone deacetylase inhibitor. - HDAC inhibitor SB939 · NCIC Clinical Trials Group · Oncology
Histone deacetylase inhibitor - Adriamycin, cyclophosphamide, vindesine, valproic acid · European Lung Cancer Working Party · Oncology
Adriamycin is an anthracycline antibiotic that intercalates DNA strands, inhibiting topoisomerase II, and inducing apoptosis. Cyclophosphamide is an alkylating agent that cross-links DNA, causing cell death. Vindesine is a vinca alkaloid that binds to tubulin, disrupting microtubule formation and cell division. Valproic acid is a histone deacetylase inhibitor that modulates gene expression.
Patent intelligence
- histone deacetylase inhibitor patent landscape — aggregated cliff calendar, attackable patents, originator estates