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HG-group
HG-group is a histone deacetylase inhibitor.
HG-group is a histone deacetylase inhibitor. Used for Treatment of various cancers.
At a glance
| Generic name | HG-group |
|---|---|
| Sponsor | Medical University of Vienna |
| Drug class | Histone deacetylase inhibitor |
| Target | Histone deacetylase |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
Mechanism of action
Histone deacetylase inhibitors, such as HG-group, work by blocking the action of histone deacetylases, which are enzymes that remove acetyl groups from histones. This leads to increased acetylation of histones, resulting in chromatin relaxation and increased gene expression. As a result, HG-group can induce cell cycle arrest and apoptosis in cancer cells.
Approved indications
- Treatment of various cancers
Common side effects
- Fatigue
- Nausea
- Diarrhea
- Vomiting
- Anemia
- Thrombocytopenia
- Neutropenia
- Leukopenia
- Anorexia
- Weight loss
Key clinical trials
- Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy (NA)
- Lung US for PEEP Optimization in Robotic Radical Prostatectomy or Cystectomy Patients (NA)
- Muscle Function After Childbirth (NA)
- Prolonged Compression Following Foam Sclerotherapy (NA)
- External Pharyngeal Exerciser and Dysphagia (NA)
- Remote Ischemic Conditioning and Spinal Reflex Modulation (NA)
- Studies of Skin Microbes in Healthy People and in People With Skin Conditions
- Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- HG-group CI brief — competitive landscape report
- HG-group updates RSS · CI watch RSS
- Medical University of Vienna portfolio CI