Atypical Antipsychotic
This page covers all Atypical Antipsychotic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Potassium voltage-gated channel subfamily H member 2, 5-hydroxytryptamine receptor 2A, Dopamine D2 receptor, Serotonin 5-HT2A receptor.
Targets
Potassium voltage-gated channel subfamily H member 2 · 5-hydroxytryptamine receptor 2A · Dopamine D2 receptor, Serotonin 5-HT2A receptor · Dopamine D2 receptor (partial agonist); Serotonin 5-HT1A receptor (partial agonist); Serotonin 5-HT2A receptor (antagonist) · D2 dopamine receptor, 5-HT2A serotonin receptor · Dopamine D2 receptor; Serotonin 5-HT2A receptor · Dopamine D2 receptor (partial agonist); Serotonin 5-HT1A receptor (agonist) · ["serotonin 5-HT2A receptors", "dopamine D2 receptors"] · Dopamine D2 receptor (partial agonist), Serotonin 5-HT1A receptor (partial agonist) · Dopamine D2 receptor, Serotonin 5-HT7 receptor
Marketed (50)
- Invega Sustenna · Johnson & Johnson · Metabolic · 3800
Invega Sustenna works by blocking a specific channel in the brain that helps regulate electrical activity. - Nuplazid · Acadia Pharms Inc · Neuroscience · 600
Nuplazid works by blocking the action of a specific chemical messenger in the brain called serotonin. - Olanzapine & Quetiapine · Hamilton Health Sciences Corporation · Psychiatry
Olanzapine and quetiapine are atypical antipsychotics that block dopamine D2 and serotonin 5-HT2A receptors to reduce psychotic symptoms and stabilize mood. - Aripiprazole tablet · All India Institute of Medical Sciences, Bhubaneswar · Psychiatry / Neurology
Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and an antagonist at serotonin 5-HT2A receptors, which stabilizes dopamine and serotonin neurotransmission in the brain. - Adjunctive asenapine · Lori Davis, MD · Psychiatry
Asenapine is an atypical antipsychotic that blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms and mood disturbances. - paliperidone clozapine · Universidad Nacional de Rosario · Psychiatry
Paliperidone and clozapine are atypical antipsychotics that block dopamine D2 and serotonin 5-HT2A receptors to reduce psychotic symptoms. - Risperdal Consta · Zogenix, Inc. · Psychiatry
Risperdal Consta is a long-acting injectable antipsychotic that blocks dopamine D2 receptors in the brain to reduce psychotic symptoms. - Risperidone Long Acting · Dartmouth-Hitchcock Medical Center · Psychiatry
Risperidone is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms and stabilize mood. - Risperidone tablets · Sumitomo Pharma (Suzhou) Co., Ltd. · Psychiatry/Neurology
Risperidone blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms and stabilize mood. - Aripiprazole or other oral antipsychotics · Otsuka Pharmaceutical Development & Commercialization, Inc. · Psychiatry
Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that modulates dopaminergic and serotonergic neurotransmission to treat psychotic and mood disorders. - Risperidone low dose · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Psychiatry
Risperidone blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms and stabilize mood. - Risperidone Long acting injectable · Janssen Pharmaceutica N.V., Belgium · Psychiatry/Neurology
Risperidone blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms and stabilize mood. - SAPHRIS · Sun Pharmaceutical Industries Limited · Psychiatry
SAPHRIS (asenapine) is an atypical antipsychotic that blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms and mood disturbances. - Quetiapine 600mg · AstraZeneca · Neuroscience
Quetiapine is an atypical antipsychotic that acts as a serotonin and dopamine receptor antagonist. - Sublingual film containing Igalmi · BioXcel Therapeutics Inc · Psychiatry
Igalmi is a fast-acting atypical antipsychotic that rapidly dissolves under the tongue to block dopamine and serotonin receptors in the brain. - olanzapine therapy · Eli Lilly and Company · Psychiatry
Olanzapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms and stabilize mood. - Risperidone high dose · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Psychiatry/Neurology
Risperidone blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms and stabilize mood. - Ziprasidone Injection · Hennepin Healthcare Research Institute · Psychiatry
Ziprasidone is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. - ziprasidone or olanzapine · Medical University of Vienna · Psychiatry
Both ziprasidone and olanzapine are atypical antipsychotics that block dopamine D2 and serotonin 5-HT2A receptors to reduce psychotic symptoms. - aripiprazole (Abilify) · Massachusetts General Hospital · Psychiatry
Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that stabilizes dopamine and serotonin neurotransmission in the brain. - Latuda (Lurasidone) · Massachusetts General Hospital · Psychiatry
Lurasidone is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT7 receptors in the brain to reduce psychotic symptoms and mood disturbances. - A-prexa · HK inno.N Corporation · Psychiatry
A-prexa is an antipsychotic medication that works by blocking dopamine receptors in the brain. - Abilify (aripiprazole) · Genovate Biotechnology Co., Ltd., · Psychiatry / Neurology
Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that helps stabilize dopamine and serotonin activity in the brain. - placebo with Clozapine · Shanghai Mental Health Center · Psychiatry
Clozapine is an atypical antipsychotic that blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms. - quetiapine (Seroquel) XR · Dr. D McIntosh & Dr. K Kjernisted Clinical Research Inc. · Psychiatry
Quetiapine is an atypical antipsychotic that blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms and stabilize mood. - full-dose olanzapine · Kaohsiung Kai-Suan Psychiatric Hospital · Psychiatry
Olanzapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. - Latuda© · University of North Carolina, Chapel Hill · Psychiatry
Latuda is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT7 receptors while acting as a partial agonist at 5-HT1A receptors. - Intramuscular aripiprazole, olanzapine · Veterans Medical Research Foundation · Psychiatry
Aripiprazole and olanzapine are atypical antipsychotics that modulate dopamine and serotonin signaling in the brain to reduce psychotic symptoms and stabilize mood. - IM aripiprazole once monthly · University of Utah · Psychiatry
Aripiprazole is a dopamine D2/D3 receptor partial agonist that modulates dopaminergic and serotonergic neurotransmission to treat schizophrenia and bipolar disorder. - risperidone (Risperdal) · University of South Florida · Psychiatry/Neurology
Risperidone blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms and stabilize mood. - Amisulpride add-on · National Health Research Institutes, Taiwan · Psychiatry
Amisulpride is a selective dopamine D2/D3 receptor antagonist that blocks dopamine signaling in the brain to reduce psychotic symptoms and improve mood. - Quetiapine Fumarate Sustained Release · AstraZeneca · Psychiatry
Quetiapine is an atypical antipsychotic that antagonizes dopamine D2 and serotonin 5-HT2A receptors in the brain. - Aripiprazole 6-week group · Seoul National University Hospital · Psychiatry
Aripiprazole is a dopamine D2/D3 receptor partial agonist that modulates dopaminergic and serotonergic neurotransmission to treat psychiatric disorders. - Paliperdidone ER · Janssen Korea, Ltd., Korea · Psychiatry
Paliperidone ER is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms. - quetiapine fumarate vs risperidone · AstraZeneca · Psychiatry/Neurology
Quetiapine fumarate is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain, while risperidone is a similar atypical antipsychotic with higher D2 receptor affinity and additional alpha-adrenergic blocking activity. - Quetiapine Immediate Release · AstraZeneca · Psychiatry
Quetiapine blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms and stabilize mood. - Aripiprazole 8-week group · Seoul National University Hospital · Psychiatry
Aripiprazole is a dopamine D2/D3 receptor partial agonist that modulates dopaminergic and serotonergic neurotransmission to treat psychotic and mood disorders. - Perospirone hydrochloride tablets · Shanghai Mental Health Center · Psychiatry/Neurology
Perospirone is an atypical antipsychotic that blocks dopamine D2 receptors and serotonin 5-HT2A receptors in the brain. - Oral Olanzapine · Eli Lilly and Company · Psychiatry
Olanzapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms and stabilize mood. - Seroquel (quetiapine) · AstraZeneca · Psychiatry
Quetiapine blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms and stabilize mood.
Phase 3 pipeline (47)
- Inhaled Loxapine · Alexza Pharmaceuticals, Inc. · Psychiatry
Inhaled loxapine is a rapid-acting antipsychotic that blocks dopamine and serotonin receptors in the brain to reduce acute agitation. - Phase 2: Olanzapine · Shanghai Mental Health Center · Psychiatry
Olanzapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. - ER OROS Paliperidone · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Psychiatry
Paliperidone is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. - Olanzapine-samidorphan； · Qilu Pharmaceutical Co., Ltd. · Psychiatry
Olanzapine-samidorphan is an atypical antipsychotic that combines the antipsychotic effects of olanzapine with the weight loss effects of samidorphan. - Asenapine - Double Blind · Organon and Co · Psychiatry/Neurology
Asenapine is an atypical antipsychotic that blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms and mood disturbances. - Zyprexa® (OLANZapine 5MG) · CR-CSSS Champlain-Charles-Le Moyne · Psychiatry
Zyprexa works by blocking the action of dopamine and serotonin in the brain, which helps to reduce symptoms of psychosis. - Experimental drug: Olanzapine · CCTU · Psychiatry/Neurology
Olanzapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. - OPC-34712 [Brexpiprazole] High Dose · Otsuka Pharmaceutical Development & Commercialization, Inc. · Psychiatry
Brexpiprazole is a partial agonist at serotonin 5-HT1A receptors and a partial agonist at dopamine D2 receptors. - SM-13496 (lurasidone HCl) · Sumitomo Pharma Co., Ltd. · Psychiatry
SM-13496 (lurasidone HCl) is an atypical antipsychotic that acts as a serotonin 2A receptor antagonist and a dopamine receptor antagonist. - Amisulpride IV Treatment · Benaroya Research Institute · Psychiatry
Amisulpride is a selective dopamine D2/D3 receptor antagonist that blocks dopamine signaling in the brain. - Aripiprazole (Titrated dose) · Otsuka Pharmaceutical Co., Ltd. · Psychiatry/Neurology
Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that modulates dopaminergic and serotonergic neurotransmission in the brain. - Paliperidone ER OROS · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Psychiatry
Paliperidone ER OROS is an atypical antipsychotic that works by blocking dopamine receptors in the brain. - OPC-14597 (Aripiprazole) · Otsuka Pharmaceutical Co., Ltd. · Psychiatry / Neurology
Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that stabilizes dopaminergic and serotonergic neurotransmission. - IM risperidone · US Department of Veterans Affairs · Psychiatry
IM risperidone is an intramuscular long-acting formulation of the atypical antipsychotic risperidone, which blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. - Olanzapine 10 milligram · Mercy Bon Secours Saint Vincent Medical Center · Psychiatry
Olanzapine blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms and stabilize mood. - OLZ/SAM · Alkermes, Inc. · Psychiatry
OLZ/SAM is an oral, fixed-dose combination of olanzapine and samidorphan, a partial agonist at the μ-opioid receptor. - Olanzapine or Quetiapine or Risperidone · Otsuka Pharmaceutical Development & Commercialization, Inc. · Psychiatry
These atypical antipsychotics block dopamine D2 and serotonin 5-HT2A receptors to reduce psychotic symptoms and stabilize mood. - Phase 1: Olanzapine · Shanghai Mental Health Center · Psychiatry
Olanzapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. - Risperdal Consta (drug) · University of Illinois at Chicago · Psychiatry
Risperdal Consta is a long-acting injectable formulation of risperidone, a second-generation antipsychotic that primarily works by blocking dopamine and serotonin receptors in the brain. - Aripiprazole (Fixed dose) · Otsuka Pharmaceutical Co., Ltd. · Psychiatry
Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that stabilizes dopamine and serotonin neurotransmission in the brain. - Aripiprazole tablets · Chengdu Kanghong Pharmaceutical Group Co., Ltd. · Psychiatry / Neurology
Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and an antagonist at serotonin 5-HT2A receptors, which stabilizes dopamine and serotonin neurotransmission in the brain. - Risperidone and placebo comparator · University of Alabama at Birmingham · Psychiatry
Risperidone is an atypical antipsychotic that acts as a dopamine D2 receptor antagonist and serotonin 5-HT2A receptor antagonist. - IM olanzapine · National Taiwan University Hospital · Psychiatry
IM olanzapine is an intramuscular formulation of olanzapine, an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. - Phase 2: Amisulpride · Shanghai Mental Health Center · Psychiatry
Amisulpride is a selective dopamine D2 and D3 receptor antagonist that blocks dopamine signaling in the brain to reduce psychotic symptoms and improve mood. - Aripiprazole and aripiprazole once-monthly · H. Lundbeck A/S · Psychiatry
Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and an antagonist at serotonin 5-HT2A receptors, which stabilizes dopamine and serotonin neurotransmission in the brain. - Risperidone, oral tablets · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Psychiatry
Risperidone is an atypical antipsychotic that acts as a dopamine D2 receptor antagonist and serotonin 5-HT2A receptor antagonist. - Olanzapine, risperidone · AstraZeneca · Psychiatry
Olanzapine and risperidone are atypical antipsychotics that work by blocking dopamine and serotonin receptors in the brain. - Lurasidone 20, 40, 60, 80 mg, flexibly dosed · Sumitomo Pharma America, Inc. · Psychiatry
Lurasidone is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT7 receptors in the brain. - Lurasidone Oral Capsule · NeuroRx, Inc. · Psychiatry/Neurology
Lurasidone is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT7 receptors to reduce psychotic symptoms and mood disturbances. - Administration of quetiapine XR · Tri-Service General Hospital · Psychiatry
Quetiapine is an atypical antipsychotic that antagonizes dopamine D2 and serotonin 5-HT2A receptors in the brain. - Phase 1: Amisulpride · Shanghai Mental Health Center · Psychiatry
Amisulpride is a selective dopamine D2 and D3 receptor antagonist that blocks dopamine signaling in the brain to reduce psychotic symptoms and improve mood. - Phase 2: Clozapine · Shanghai Mental Health Center · Psychiatry
Clozapine is an atypical antipsychotic that blocks dopamine D2 receptors and serotonin 5-HT2A receptors in the brain. - Paliperidone and paliperidone palmitate · H. Lundbeck A/S · Psychiatry/Neurology
Paliperidone is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms. - Placebo Asenapine · Organon and Co · Psychiatry
Asenapine is an atypical antipsychotic that blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms and mood disturbances. - Intramuscular Olanzapine Depot · Eli Lilly and Company · Psychiatry
Olanzapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain to reduce psychotic symptoms and stabilize mood. - olanzapine pamoate depot · Eli Lilly and Company · Psychiatry
Olanzapine pamoate depot is a long-acting intramuscular formulation of olanzapine, an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. - Phase 1: Aripiprazole · Shanghai Mental Health Center · Psychiatry
Aripiprazole is a dopamine D2/D3 receptor partial agonist that modulates dopaminergic and serotonergic neurotransmission in the brain. - Phase 1: Risperidone · Shanghai Mental Health Center · Psychiatry
Risperidone is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain. - Lurasidone HC1 · Sumitomo Pharma America, Inc. · Psychiatry
Lurasidone is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT7 receptors in the brain. - Hydrochloride Carliprazine capsules · Chengdu Kanghong Pharmaceutical Group Co., Ltd. · Psychiatry/Neurology
Carliprazine is an atypical antipsychotic that acts as a dopamine D2/D3 receptor partial agonist and serotonin 5-HT1A receptor partial agonist.
Phase 2 pipeline (1)
- Augment with Aripiprazole · Shanghai Mental Health Center · Psychiatry / Neurology
Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that modulates dopaminergic and serotonergic neurotransmission in the brain.
Phase 1 pipeline (3)
- 14C-paliperidone · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Neurology
Dopamine D2 receptor antagonist - Amisulpride IV · Acacia Pharma Ltd · Neurology
Dopamine D2/D3 receptor antagonist - Antipsychotic therapy · FORUM Pharmaceuticals Inc · Neurology
Antagonizes dopamine D2 receptors