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Olanzapine, risperidone
Olanzapine and risperidone are atypical antipsychotics that work by blocking dopamine and serotonin receptors in the brain.
Olanzapine and risperidone are atypical antipsychotics that work by blocking dopamine and serotonin receptors in the brain. Used for Treatment of schizophrenia, Treatment of bipolar disorder.
At a glance
| Generic name | Olanzapine, risperidone |
|---|---|
| Sponsor | AstraZeneca |
| Drug class | atypical antipsychotic |
| Target | D2 receptor, 5-HT2A receptor |
| Modality | Small molecule |
| Therapeutic area | Psychiatry |
| Phase | Phase 3 |
Mechanism of action
They are primarily used to treat schizophrenia and bipolar disorder. By blocking dopamine and serotonin receptors, they help to reduce symptoms of psychosis and mania.
Approved indications
- Treatment of schizophrenia
- Treatment of bipolar disorder
Common side effects
- Weight gain
- Dizziness
- Headache
- Nausea
- Somnolence
Key clinical trials
- An Exploratory Analysis of Immune and Inflammatory Response Associated With Clozapine (PHASE4)
- Supported Employment and Skills Training in Conjunction With Pharmacotherapy in Schizophrenia Patients (PHASE4)
- Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. (PHASE4)
- Enhancing Recovery in Early Schizophrenia (PHASE2)
- National Pregnancy Registry for Psychiatric Medications
- Maternal And Infant Antipsychotic Study
- Study Comparing Antipsychotic Dose Reduction vs. Maintenance Treatment in Patients With Schizophrenia Spectrum Disorder: a Personalized Medicine Approach (PHASE2)
- Whole Blood and Plasma Sample Collection for the Development of Antipsychotic Immunoassays From Participants Taking Aripiprazole, Olanzapine, Paliperidone, or Risperidone (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Olanzapine, risperidone CI brief — competitive landscape report
- Olanzapine, risperidone updates RSS · CI watch RSS
- AstraZeneca portfolio CI